Evidence map›Paper›PMID 40319875›Full record

Trial reportGynecologic and obstetric investigation2026

Oral Drospirenone/Estetrol as Rapid and Random Start Endometrial Preparation before Office Hysteroscopic Polypectomy: A Multicenter, Prospective, Randomized Controlled Trial.

Andrea Etrusco, Vittorio Agrifoglio, Vito Chiantera, Giuseppe Russo, Tullio Golia D Apos Augè, Marco Monti, Andrea Giannini, Gaetano Riemma, Giuseppe Scibilia, Basilio Pecorino and 2 more

RetractedAbstract readRandomized Controlled TrialMulticenter StudyRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Gynecologic and obstetric investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Andrea EtruscoUnit of Obstetrics and Gynecology, "Paolo Giaccone" Hospital, Palermo, Italy.
Vittorio AgrifoglioUnit of Obstetrics and Gynecology, "Paolo Giaccone" Hospital, Palermo, Italy.
Vito ChianteraDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Palermo, Italy.
Giuseppe RussoEcole Polytechnique fédérale de Lausanne - Department of Computer and Communication Sciences (EDIC), Lausanne, Switzerland.
Tullio Golia D Apos AugèDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, Rome, Italy.
Marco MontiDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, Rome, Italy.
Andrea GianniniUnit of Gynecology, Department of Surgical and Medical Sciences and Translational Medicine, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.
Gaetano RiemmaDepartment of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Giuseppe ScibiliaGynecology and Obstetrics Department, Giovanni Paolo II Hospital, ASP 7, Ragusa, Italy.
Basilio PecorinoGynecology and Obstetrics Unit, Department of Medicine and Surgery, Umberto I Hospital Enna, University of Enna "Kore", Enna, Italy.
Antonio D'AmatoDepartment of Interdisciplinary Medicine (DIM), Unit of Obstetrics and Gynecology, University of Bari "Aldo Moro", Policlinico of Bari, Bari, Italy, antoniodamato19@libero.it.
Antonio Simone LaganàUnit of Obstetrics and Gynecology, "Paolo Giaccone" Hospital, Palermo, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesEndometrial preparation provides significant surgical benefits prior to hysteroscopic procedures. However, there is still no consensus on the optimal presurgical protocol. Although there is evidence on rapid preparation, there are currently no studies on rapid endometrial preparation using combined oral contraceptives initiated at a "random" time in the menstrual cycle. The aim of the present trial was to evaluate the use of oral drospirenone/estetrol in random start rapid preparation of endometrium before office hysteroscopic polypectomy.

designIn this multicenter, prospective, randomized controlled trial, 80 women scheduled for polypectomy were randomly assigned to intervention (n = 40) or control (n = 40) groups. PARTICIPANTS/MATERIALS, SETTING,

methodsThe intervention group received oral drospirenone/estetrol (3 mg/14.2 mg/day) for 14 days, starting at any menstrual cycle point (random start). Controls underwent polypectomy on cycle days 8-11 without any prior pharmacological intervention.

resultsPre- and post-procedure, endometrial thickness was significantly lower in the drospirenone/estetrol group (p < 0.001), and patients showed more hypotrophic/atrophic endometrial patterns (p < 0.001). Operative time, distension medium usage, incomplete resections, and bleeding during polypectomy were significantly lower in the drospirenone/estetrol group (p < 0.001). Endometrial preparation quality, uterine cavity visualization, and procedure satisfaction were higher in the drospirenone/estetrol group (p < 0.001). Furthermore, patients in the drospirenone/estetrol group experienced less pain during (p < 0.001) and after the procedure (p < 0.001), requiring fewer analgesics (p < 0.001) and shorter post-procedure discharge time (p = 0.01) than controls. LIMITATIONS: Limited sample size; possible variability due to different hysteroscopists, caused by the multicenter nature of the study; hysteroscopists were unmasked to treatment allocation; absence of a cost-effectiveness analysis.

conclusionsTreatment with drospirenone/estetrol could provide rapid, satisfactory and low-cost endometrial preparation before office polypectomy, improving surgical performance and patient compliance.

Indexed as

AndrostenesEndometriumEstetrolHysteroscopyPolypsPreoperative CareAdministration, OralAdultDrug CombinationsFemaleHumansMiddle AgedProspective StudiesAndrostenesdrospirenoneDrug CombinationsEstetrolCombined oral contraceptivesDrospirenoneEndometrial polypsEstetrolHysteroscopyPreoperative treatment

Identifiers

PMID40319875
PMCPMC13061394

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.