Evidence map›Paper›PMID 40319431›Full record

SynthesisInternational urology and nephrology2025

Association of estimated glomerular filtration rate with proliferative diabetic retinopathy: a systematic review and meta-analysis.

Prakasini Satapathy, Abhay M Gaidhane, Nasir Vadia, Soumya V Menon, Kattela Chennakesavulu, Rajashree Panigrahi, Sanjit Sah, Ambana Yappalparvi, S Govinda Rao, Khang Wen Goh and 5 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in International urology and nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Prakasini Satapathy *Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
Abhay M Gaidhane *Jawaharlal Nehru Medical College, and Global Health Academy, School of Epidemiology and Public Health, Datta Meghe Institute of Higher Education, Wardha, India.
Nasir VadiaMarwadi University Research Center, Department of Pharmaceutical Sciences, Faculty of Health Sciences, Marwadi University, Rajkot, 360003, Gujarat, India.
Soumya V MenonDepartment of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, India.
Kattela ChennakesavuluDepartment of Chemistry, Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu, India.
Rajashree PanigrahiDepartment of Microbiology, IMS and SUM Hospital, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, 751003, India.
Sanjit SahDepartment of Paediatrics, Dr. D. Y. Patil Medical College Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed-to-be-University), Pimpri, Pune, 411018, Maharashtra, India.
Ambana Yappalparvi *Centre for Research Impact and Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, 140401, Punjab, India.
S Govinda RaoDepartment of Data Science, Gokaraju Rangaraju Institute of Engineering and Technology, Bachupally, Hyderabad, 500090, Telangana, India.
Khang Wen GohFaculty of Data Science and Information Technology, INTI International University, Nilai, Malaysia.
Rachana MehtaClinical Microbiology, RDC, Manav Rachna International Institute of Research and Studies, Faridabad, Haryana, 121004, India.
Muhammed ShabilUniversity Center for Research and Development, Chandigarh University, Mohali, Punjab, India.
Mahendra SinghDepartment of Biotechnology, Graphic Era (Deemed to be University), Clement Town, Dehradun, 248002, India.
Edward MawejjeSchool of Public Health, Makerere University College of Health Sciences, Mulago Hill, Kampala, Uganda. emawejje62@gmail.com.
Ganesh BushiChitkara Centre for Research and Development, Chitkara University Institute of Engineering and Technology, Chitkara University, Baddi, Himachal Pradesh, 174103, India. ganeshbushi313@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProliferative diabetic retinopathy (PDR) is a serious vision-threatening complication of diabetes. Chronic kidney disease (CKD), measured by estimated glomerular filtration rate (eGFR), shares similar pathophysiological mechanisms with diabetic retinopathy, including inflammation, oxidative stress, and vascular dysfunction. However, the strength of the association between eGFR and PDR remains unclear. This review evaluates the association between reduced eGFR and the risk of PDR in individuals with diabetes.

methodsA comprehensive literature search was conducted in PubMed, Embase, and Web of Science, from inception to October 2024. Observational studies reporting both eGFR values and PDR status were included. Study quality was assessed using the Newcastle-Ottawa Scale. Pooled standardized mean differences (SMD) were calculated using a fixed-effects model when heterogeneity was low (I

resultsA total of 11 studies were included, comprising 602 patients with PDR and 5,475 individuals without diabetic retinopathy. The pooled SMD for eGFR between PDR and non-PDR groups was - 0.43 (95% CI - 0.52 to - 0.34; P < 0.0001), indicating significantly lower eGFR in PDR patients. Heterogeneity was moderate (I

conclusionsThis systematic review and meta-analysis found a significant association between reduced eGFR and PDR in patients with diabetes, with consistent findings across studies and eGFR estimation methods. Though heterogeneity suggests caution in interpretation. Additional prospective using standardized methodologies are needed to clarify causality and enhance risk prediction.

Indexed as

Diabetic RetinopathyGlomerular Filtration RateHumansChronic kidney diseaseDiabetic retinopathyeGFRMeta-analysisProliferative diabetic retinopathy

Identifiers

PMID40319431

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.