Evidence map›Paper›PMID 40319395›Full record

ArticleNano letters2025

Development of Chemical Tags for Universal Lipid Nanoparticle Visualization and Tracking in 2D and 3D Imaging.

Hannia V Balcorta, Mario Y Mata Corral, Angel Gallegos, Jael Chavez, Jose Perez, Sivasai Balivada, Sylvia L Natividad-Diaz, Wilson Poon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nano letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hannia V BalcortaDepartment of Metallurgical, Materials, and Biomedical Engineering, College of Engineering, The University of Texas at El Paso, 500 W. University Ave., El Paso, Texas 79968, United States.
Mario Y Mata CorralDepartment of Metallurgical, Materials, and Biomedical Engineering, College of Engineering, The University of Texas at El Paso, 500 W. University Ave., El Paso, Texas 79968, United States.
Angel GallegosDepartment of Metallurgical, Materials, and Biomedical Engineering, College of Engineering, The University of Texas at El Paso, 500 W. University Ave., El Paso, Texas 79968, United States.
Jael ChavezDepartment of Metallurgical, Materials, and Biomedical Engineering, College of Engineering, The University of Texas at El Paso, 500 W. University Ave., El Paso, Texas 79968, United States.
Jose PerezDepartment of Metallurgical, Materials, and Biomedical Engineering, College of Engineering, The University of Texas at El Paso, 500 W. University Ave., El Paso, Texas 79968, United States.
Sivasai BalivadaDepartment of Biological Sciences, College of Science, The University of Texas at El Paso, 500 W. University Ave., El Paso, Texas 79968, United States.
Sylvia L Natividad-DiazDepartment of Metallurgical, Materials, and Biomedical Engineering, College of Engineering, The University of Texas at El Paso, 500 W. University Ave., El Paso, Texas 79968, United States.ORCID 0000-0002-1928-829X
Wilson PoonDepartment of Metallurgical, Materials, and Biomedical Engineering, College of Engineering, The University of Texas at El Paso, 500 W. University Ave., El Paso, Texas 79968, United States.ORCID 0000-0003-2192-3077

Funding

UTEP Border Biomedical Research CenterU54MD007592 · NIMHD · UNIVERSITY OF TEXAS EL PASO · PI Gabriel Andrew Frietze · 2019 to 2026
$35.1M
Build-out of an Imaging and Behavioral Neuroscience Facility for Hispanic Health Disparities at UTEPC06OD032074 · OD · UNIVERSITY OF TEXAS EL PASO · PI KENNEY, MICHAEL J · 2021 to 2021
$5.1M
NIH HHS C06 OD032074NIMHD NIH HHS U54 MD007592
6 · The paper itself

Abstract

Precise delivery of therapeutic agents to specific cells and subcellular compartments is crucial for effective disease treatment. Lipid nanoparticles (LNPs) are promising drugs and gene nanocarriers, but understanding their transport within cells and tissues remains limited. We developed SPARKLE (Strategic Peptide, Anchored, Retained, and Kept after Lipid Elimination), a fluorescent peptide tag designed to track LNPs with advanced optical imaging techniques that involve lipid disruption (e.g., cell permeabilization or tissue clearing). Unlike conventional lipophilic dyes that wash out during lipid disruption, SPARKLE tags are retained and fluorescently mark the positions of LNPs. As proof of concept, we demonstrated the utility of SPARKLE tags by tracking LNPs

Indexed as

Fluorescent DyesImaging, Three-DimensionalLipidsNanoparticlesOptical ImagingPeptidesAnimalsHumansLiposomesMiceFluorescent DyesLipid NanoparticlesLipidsLiposomesPeptidesbioconjugate chemistrycell paintingfluorescence imaginglipid nanoparticlesnanomedicine

Identifiers

PMID40319395
PMCPMC12082698

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.