Evidence map›Paper›PMID 40319266›Full record

ArticleNeurological research and practice2025

Neurological disorders caused by recreational use of nitrous oxide-a retrospective study from a German metropolitan area and review of the literature.

Asya Tshagharyan, Se-Jong You, Christian Grefkes, Elke Hattingen, Joachim P Steinbach, Pia S Zeiner, Marcel Hildner, Iris Divé

Abstract read
In one paragraph

Article in Neurological research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Asya TshagharyanDepartment of Neurology, Goethe University Frankfurt, University Hospital, 60528, Frankfurt, Germany.
Se-Jong YouInstitute of Neuroradiology, Goethe University Frankfurt, University Hospital, 60528, Frankfurt, Germany.
Christian GrefkesDepartment of Neurology, Goethe University Frankfurt, University Hospital, 60528, Frankfurt, Germany.
Elke HattingenInstitute of Neuroradiology, Goethe University Frankfurt, University Hospital, 60528, Frankfurt, Germany.
Joachim P SteinbachDepartment of Neurology, Goethe University Frankfurt, University Hospital, 60528, Frankfurt, Germany.
Pia S ZeinerDepartment of Neurology, Goethe University Frankfurt, University Hospital, 60528, Frankfurt, Germany.
Marcel HildnerDepartment of Neurology, Goethe University Frankfurt, University Hospital, 60528, Frankfurt, Germany.
Iris DivéDepartment of Neurology, Goethe University Frankfurt, University Hospital, 60528, Frankfurt, Germany. dive@med.uni-frankfurt.de.ORCID http://orcid.org/0000-0003-1096-5626

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe recreational use of nitrous oxide (N

methodsWe screened the database of the University Hospital Frankfurt for patients ≥ 18 years of age who presented with neurological deficits and a history of N

resultsWe identified a total of 20 patients, 16 males and 4 females, with a median age of 21 years. We found a steady increase in the number of cases, with no cases in 2020 and 2021 and a definite peak in 2024. The mean daily N

conclusionsOur study confirms that the increasing incidence of N

Indexed as

GermanyMyelopathyNitrous oxidePolyneuropathy

Identifiers

PMID40319266
PMCPMC12049779

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.