Evidence map›Paper›PMID 40319232›Full record

Trial reportBMC anesthesiology2025

Effect of nebulized dexmedetomidine on gag reflex suppression and sedation quality in pediatric patients undergoing gastrointestinal endoscopy: a randomized controlled trial.

Esra Turunc, Yasemin Burcu Ustun, Sezgin Bilgin, Cengiz Kaya, Ersin Koksal, Burhan Dost

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06218797 nacompletednot on this map

Effect of Nebulized Dexmedetomidine on Gag Reflex Suppression in Pediatric Upper Gastrointestinal Endoscopy: a Randomized Controlled Trial

TypeinterventionalSponsorOndokuz Mayıs UniversityRan2024 to 2024Enrolled108ConditionsPediatric, SedationArmsa routine sedation protocol, Nebulized with dexmedetomidine
NCT07077200 completednot on this map

Comparison of Intranasal Dexmedetomidine and Short Video Viewing in the Management of Preoperative Anxiety and Sedation in Pediatric Endoscopy

TypeobservationalSponsorSamsun UniversityRan2025 to 2025Enrolled50ConditionsAnesthesia, Sedation, AnxietyArmsIntranasal dexmedetomidine
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Esra TuruncDepartment of Anesthesiology and Reanimation, Faculty of Medicine, Ondokuz Mayis University, Kurupelit, Samsun, TR55139, Turkey. esra.kiymaz.ek@gmail.com.
Yasemin Burcu UstunDepartment of Anesthesiology and Reanimation, Faculty of Medicine, Ondokuz Mayis University, Kurupelit, Samsun, TR55139, Turkey.
Sezgin BilginDepartment of Anesthesiology and Reanimation, Faculty of Medicine, Ondokuz Mayis University, Kurupelit, Samsun, TR55139, Turkey.
Cengiz KayaDepartment of Anesthesiology and Reanimation, Faculty of Medicine, Ondokuz Mayis University, Kurupelit, Samsun, TR55139, Turkey.
Ersin KoksalDepartment of Anesthesiology and Reanimation, Faculty of Medicine, Ondokuz Mayis University, Kurupelit, Samsun, TR55139, Turkey.
Burhan DostDepartment of Anesthesiology and Reanimation, Faculty of Medicine, Ondokuz Mayis University, Kurupelit, Samsun, TR55139, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPediatric patients undergoing upper gastrointestinal (GI) interventions frequently require sedation and analgesia due to the challenges associated with endoscopic probe placement, particularly the gag reflex. This study investigates the effects of nebulized dexmedetomidine as a premedication on the gag reflex in pediatric patients undergoing gastrointestinal endoscopy.

methodsWe conducted a single-center, prospective, randomized controlled trial at the Pediatric Gastroenterology Clinic of Ondokuz Mayis University School of Medicine from January to April 2024. Participants aged 2-17 years scheduled for upper GI endoscopy were randomized to receive nebulized dexmedetomidine (2 µg /kg) or no premedication. The primary outcome measured was the severity of the gag reflex during the procedure. Secondary outcomes included cough incidence, separation anxiety, postoperative agitation, and endoscopist satisfaction. Statistical analyses were performed with significance set at p < 0.050.

resultsA total of 120 patients were analyzed. The dexmedetomidine group demonstrated a significantly lower incidence of gag reflex (88.3% with no gag reflex vs. 30% in the control group, p < 0.001) and coughing (95% vs. 55%, p < 0.001). Separation anxiety scores were also significantly lower in the dexmedetomidine group (p < 0.005). Additionally, the need for additional anesthetics was reduced, and endoscopist satisfaction was significantly higher. No significant differences in complications were observed between the two groups (p = 0.600).

conclusionsNebulized dexmedetomidine is a safe and effective premedication for pediatric patients undergoing endoscopic procedures, significantly reducing gag and cough reflexes, decreasing anesthetic requirements, and enhancing endoscopist satisfaction. This approach improves the comfort and safety of pediatric endoscopy procedures. TRIALS REGISTRATION: ClinicalTrials.gov: NCT06218797, date of registration 27/12/2023.

Indexed as

DexmedetomidineEndoscopy, GastrointestinalGaggingHypnotics and SedativesProcedural SedationAdolescentChildChild, PreschoolFemaleHumansMaleNebulizers and VaporizersProspective StudiesDexmedetomidineHypnotics and SedativesEndoscopyGag reflexNebulized dexmedetomidinePediatric anesthesiaSedation

Identifiers

PMID40319232
PMCPMC12048968

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.