Evidence map›Paper›PMID 40319219›Full record

ArticleAnnals of biomedical engineering2025

Elevated Contact Stresses Compromise Activity-Mediated Cartilage Rehydration but not Lubrication.

Shamimur R Akanda, Meghan E Kupratis, Arnab Bhattacharjee, Jamie Benson, David L Burris, Christopher Price

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In one paragraph

Article in Annals of biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shamimur R AkandaMechanical Engineering, University of Delaware, Newark, DE, USA.ORCID http://orcid.org/0009-0000-9419-6662
Meghan E KupratisBiomedical Engineering Department, University of Delaware, 590 Avenue 1743, Newark, DE, USA.
Arnab BhattacharjeeMechanical Engineering, University of Delaware, Newark, DE, USA.
Jamie BensonBiomedical Engineering Department, University of Delaware, 590 Avenue 1743, Newark, DE, USA.
David L BurrisMechanical Engineering, University of Delaware, Newark, DE, USA.
Christopher PriceMechanical Engineering, University of Delaware, Newark, DE, USA. cprice@udel.edu.ORCID http://orcid.org/0000-0001-6573-6551

Funding

Division of Civil, Mechanical and Manufacturing Innovation NSF BMMB 1635536
6 · The paper itself

Abstract

purposeUnderstanding how obesity-a key risk factor for osteoarthritis-effects articular cartilage function is critical to understand OA pathoetiology. Cartilage, a biphasic material, supports vanishingly low friction coefficients in vivo, but is tribomechanically compromised by load-induced interstitial pressure/lubrication loss. To maintain tribomechanical function, cartilage must recover fluid lost to habitual/average contact stresses, a problem obesity likely exacerbates. Recently, we have shown that articulation/sliding drives robust interstitial fluid recovery and indefinite maintenance of biofidelic tissue strains and frictions through generation of hydrodynamic pressures within cartilage contact interfaces, i.e., via 'tribological rehydration.' However, the impact of elevated contact stresses on tribological rehydration and cartilage's function/lubrication remains unknown.

methodsUsing our convergent stationary contact area (cSCA) testing approach on ovine stifle cartilage explants bathed in PBS, we aimed to elucidate several points: (1) the effect of elevated contact stress on tribological rehydration during high-speed articulation, and how (2) cartilage material properties and (3) sliding speed influence contact stress-dependent fluid exudation, rehydration, and lubrication.

resultsOverall, we identified that (i) contact stress, across a narrow range, and (ii) static loading time are key controllers of tribological rehydration magnitude, compression accumulation, and equilibrium/total compression under biofidelic cSCA loading and sliding conditions. However, over the range tested (i.e., 0.2-0.8 MPa), (iii) contact stresses had no appreciable effect on cartilage's remarkable lubricity in the cSCA.

conclusionsThese results show that obesity is likely to directly physically impair articular cartilage function, and that obesity-driven tissue compression/strain, and not friction per se, may be the primary mechanical driver of cartilage dysfunction and OA risk.

Indexed as

Cartilage, ArticularObesityStress, MechanicalAnimalsFrictionLubricationSheepCartilage indentationCartilage mechanical propertiesCartilage tribologyInterstitial lubricationMismatch disease

Identifiers

PMID40319219
PMCPMC12185574

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.