Evidence map›Paper›PMID 40319182›Full record

SynthesisJournal of human hypertension2025

Blood pressure response to mineralocorticoid receptor antagonists or aldosterone synthase inhibitors according to baseline renin levels.

Ana Rita Leite, António Angélico-Gonçalves, Adelino Leite-Moreira, João Sérgio Neves, João Pedro Ferreira

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Journal of human hypertension, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Mineralocorticoid Receptor Antagonists in Dialysis.American journal of nephrology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ana Rita LeiteRISE-Health, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal. ana.leite7c@gmail.com.
António Angélico-GonçalvesRISE-Health, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal.ORCID http://orcid.org/0000-0003-2765-1738
Adelino Leite-MoreiraRISE-Health, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal.
João Sérgio NevesRISE-Health, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal.
João Pedro FerreiraRISE-Health, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal.ORCID http://orcid.org/0000-0002-2304-6138

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plasma renin is a surrogate marker of sodium retention in hypertension, and its levels are suppressed in conditions of heightened aldosterone production. We performed a random-effects meta-analysis of randomized clinical trials focusing on the impact of mineralocorticoid receptor antagonists (MRA) and aldosterone synthase inhibitors (ASi) on blood pressure according to baseline renin levels. We included four randomized clinical trials, and we found that the response to MRA or ASi was independent of baseline plasma renin levels.

Indexed as

Antihypertensive AgentsBlood PressureCytochrome P-450 CYP11B2Enzyme InhibitorsHypertensionMineralocorticoid Receptor AntagonistsReninHumansRandomized Controlled Trials as TopicAntihypertensive AgentsCytochrome P-450 CYP11B2Enzyme InhibitorsMineralocorticoid Receptor AntagonistsRenin

Identifiers

PMID40319182

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.