Evidence map›Paper›PMID 40319158›Full record

ArticleScientific reports2025

Divergent immediate and delayed effects of juvenile exposure to doxorubicin on the thymus in C57BL/6 mice.

Benu George, Korbyn J V Dahlquist, Marianne K O Grant, Mary R Daniel, Declan M Smith, Ian Ahlberg, Karim T Sadak, Davis Seelig, Christina D Camell, Beshay N Zordoky

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Benu George *Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.
Korbyn J V Dahlquist *Department of Biochemistry, Molecular Biology, and Biophysics, Medical School, University of Minnesota, Minneapolis, MN, USA.
Marianne K O GrantDepartment of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.
Mary R DanielDepartment of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.
Declan M SmithMasonic Institute on the Biology of Aging and Metabolism, Medical School, University of Minnesota, Minneapolis, MN, USA.
Ian AhlbergDepartment of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.
Karim T SadakDepartment of Pediatrics, Division of Pediatric Hematology and Oncology, Medical School, University of Minnesota, Minneapolis, USA.
Davis SeeligComparative Pathology Shared Resource, Masonic Cancer Center, and College of Veterinary Medicine, University of Minnesota, St. Paul, MN, USA.
Christina D CamellDepartment of Biochemistry, Molecular Biology, and Biophysics, Medical School, University of Minnesota, Minneapolis, MN, USA.
Beshay N ZordokyDepartment of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA. zordo001@umn.edu.

Funding

Psychosocial Stress Exacerbates Doxorubicin-induced Cardiovascular AgingR01HL151740 · NHLBI · UNIVERSITY OF MINNESOTA · PI ZORDOKY, BESHAY · 2020 to 2024
$3.2M
NHLBI NIH HHS R01 HL151740NHLBI NIH HHS R01HL151740
6 · The paper itself

Abstract

The long-term effects of doxorubicin (DOX) chemotherapy on thymic immune function in childhood cancer survivors remain inadequately understood. This study explores the immediate and delayed impacts of low-dose DOX on thymic immune populations using a juvenile mouse model. Male mice received intraperitoneal DOX injections (4 mg/kg/week) for three weeks, with evaluations performed at one- and five-weeks post treatment. Thymic samples were collected and analyzed using multi-parameter flow cytometry to assess changes in immune cell composition and phenotype. Additionally, real-time polymerase chain reaction (RT-PCR) was employed to measure gene expression of cytokines and senescence markers. One week after DOX administration, significant thymic atrophy was evident. While mature CD3

Indexed as

Antibiotics, AntineoplasticDoxorubicinThymus GlandAnimalsCytokinesMaleMiceMice, Inbred C57BLT-Lymphocyte SubsetsAntibiotics, AntineoplasticCytokinesDoxorubicinDoxorubicinImmune cellsSenescenceT-cellsThymocytesThymus

Identifiers

PMID40319158
PMCPMC12049473

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.