Evidence map›Paper›PMID 40319154›Full record

ArticleNPJ digital medicine2025

Mitigating the risk of health inequity exacerbated by large language models.

Yuelyu Ji, Wenhe Ma, Sonish Sivarajkumar, Hang Zhang, Eugene M Sadhu, Zhuochun Li, Xizhi Wu, Shyam Visweswaran, Yanshan Wang

Abstract read
In one paragraph

Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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  13. Predicting hospice eligibility among dementia patients using language models.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuelyu JiDepartment of Information Science, University of Pittsburgh, Pittsburgh, PA, USA.
Wenhe MaDepartment of Health Information Management, University of Pittsburgh, Pittsburgh, PA, USA.
Sonish SivarajkumarIntelligent Systems Program, University of Pittsburgh, Pittsburgh, PA, USA.
Hang ZhangIntelligent Systems Program, University of Pittsburgh, Pittsburgh, PA, USA.
Eugene M SadhuDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, USA.
Zhuochun LiDepartment of Information Science, University of Pittsburgh, Pittsburgh, PA, USA.
Xizhi WuDepartment of Health Information Management, University of Pittsburgh, Pittsburgh, PA, USA.
Shyam VisweswaranDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA, USA.
Yanshan WangDepartment of Health Information Management, University of Pittsburgh, Pittsburgh, PA, USA. yanshan.wang@pitt.edu.

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR001857 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2016 to 2025
$129.3M
ENACT: Translating Health Informatics Tools to Research and Clinical Decision MakingU24TR004111 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STEVEN E REIS, SHYAM VISWESWARAN · 2022 to 2026
$23.3M
The Pediatric Precision Sleep NetworkU01MH136020 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JALBRZIKOWSKI, MARIA, MCMAKIN, DANA L · 2024 to 2025
$7.2M
Closing the loop with an automatic referral population and summarization systemR01LM014306 · NLM · WEILL MEDICAL COLL OF CORNELL UNIV · PI Yifan Peng, Justin Frederick Rousseau · 2023 to 2026
$2.7M
NCATS NIH HHS U24 TR004111NCATS NIH HHS UL1 TR001857NIH HHS R01 LM014306NIH HHS U24 TR004111NIMH NIH HHS U01 MH136020NLM NIH HHS R01 LM014306
6 · The paper itself

Abstract

Recent advancements in large language models (LLMs) have demonstrated their potential in numerous medical applications, particularly in automating clinical trial matching for translational research and enhancing medical question-answering for clinical decision support. However, our study shows that incorporating non-decisive socio-demographic factors, such as race, sex, income level, LGBT+ status, homelessness, illiteracy, disability, and unemployment, into the input of LLMs can lead to incorrect and harmful outputs. These discrepancies could worsen existing health disparities if LLMs are broadly implemented in healthcare. To address this issue, we introduce EquityGuard, a novel framework designed to detect and mitigate the risk of health inequities in LLM-based medical applications. Our evaluation demonstrates its effectiveness in promoting equitable outcomes across diverse populations.

Identifiers

PMID40319154
PMCPMC12049425

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.