Evidence map›Paper›PMID 40319119›Full record

Trial reportClinical oral investigations2025

Change in the size of apical radiolucencies in adolescent's mature maxillary incisors following retreatment with two regenerative endodontic techniques: a 12-month randomised clinical trial using volume-based cone-beam computed tomography.

Norhan Khaled Omar Wahba, Sherif Shafik E L Bahnasy, Yassmin Mohamed ElMakawi, Paul M H Dummer, Venkateshbabu Nagendrababu, Giampiero Rossi-Fedele, Francesc Abella Sans, Damiano Pasqualini, Mario Alovisi, Mohammed Turky and 2 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Norhan Khaled Omar WahbaDemonstrator of Paediatric and Community Dentistry, Faculty of Oral and Dental Medicine, Nahda University, New Bani Suef, Egypt.ORCID http://orcid.org/0009-0005-5339-2233
Sherif Shafik E L BahnasyLecturer of Oral Radiology, Faculty of Dentistry, The British University in Egypt, Al Shorouk City, Egypt.ORCID http://orcid.org/0000-0003-2380-2519
Yassmin Mohamed ElMakawiLecturer of Paediatric and Community Dentistry, Faculty of Oral and Dental Medicine, Nahda University, New Bani Suef, Egypt.ORCID http://orcid.org/0000-0002-7121-0182
Paul M H DummerSchool of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK.ORCID http://orcid.org/0000-0002-0726-7467
Venkateshbabu NagendrababuDepartment of Preventive and Restorative Dentistry, College of Dental Medicine, University of Sharjah, Sharjah, UAE.ORCID http://orcid.org/0000-0003-3783-3156
Giampiero Rossi-FedeleAdelaide Dental School, University of Adelaide, Adelaide, South Australia, Australia.ORCID http://orcid.org/0000-0002-8287-1226
Francesc Abella SansDepartment of Endodontics, School of Dentistry, Universitat International de Catalunya, Sant Cugat del Valles, Barcelona, Spain.ORCID http://orcid.org/0000-0002-3500-3039
Damiano PasqualiniDepartment of Surgical Sciences, Dental School, University of Turin, Turin, Italy.ORCID http://orcid.org/0000-0003-0365-0626
Mario AlovisiDepartment of Surgical Sciences, Dental School, University of Turin, Turin, Italy.ORCID http://orcid.org/0000-0003-2523-8149
Mohammed TurkyDepartment of Endodontics, Faculty of Dentistry, Minia University, Minia, Egypt.ORCID http://orcid.org/0000-0002-4250-9951
Eman Farouk AhmedMicrobiology and Immunology Department, Faculty of Pharmacy, Sohag University, Sohag, 82524, Province, Egypt.ORCID http://orcid.org/0000-0003-0911-2503
Ahmad Abdel Hamid ElheenyPaediatric and Community Dentistry, Faculty of Dentistry, Minia University, Province, 61519, Minya, Egypt. ahmedelheeny@mu.edu.eg.ORCID http://orcid.org/0000-0001-7796-0198

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe primary aim of this randomised clinical trial was to compare the one year clinical and radiographic outcome of mature permanent central incisors with periapical radiolucencies in adolescents after root canal retreatment using two regenerative endodontic procedures (REPs) with revitalization using induced blood clot formation (BC) or platelet-rich fibrin (PRF) evaluated with cone-beam computed tomography (CBCT). The secondary aim was to assess the responses of the teeth to thermal and electric pulp tests. MATERIALS AND

methodsFifty-four root filled maxillary central incisors with post-treatment endodontic disease and periapical radiolucencies in 48 adolescents were allocated into two groups (n = 27) using permuted block randomisation. The teeth in one group were root canal retreated with induced BC formation and teeth in the other with PRF. At baseline and at one year, teeth were evaluated clinically and radiographically using periapical radiographs and CBCT scans. Changes in the maximum diameter and volume of the periapical lesions were assessed and pulp sensibility was assessed at one year using thermal and electrical tests. Differences in lesion diameter and volume between the two groups were tested using the Mann-Whitney U test. A linear regression model explored the relationship between independent variables and lesion size. The significant level was set at 5%.

resultsReduction in periapical lesion size in the BC and PRF techniques occurred in 85% and 100% of teeth, respectively, with no significant difference. In the BC group, the mean lesion volume diminished from 0.33 ± 0.18 cm

conclusionsREPs using BC or PRF techniques when retreating root canal-treated mature permanent central incisors in adolescents with apical radiolucencies had comparable clinical and radiographic outcomes one year following treatment associated with significantly more positive responses to thermal and electric pulp tests in the PRF group. CLINICAL RELEVANCE: Retreatment of mature permanent teeth with apical periodontitis using regenerative endodontic procedures (REPs) is a new and promising approach. REPs with platelet-rich fibrin (PRF) and revascularization techniques provided high and comparable clinical and radiographic success rates.

Indexed as

Cone-Beam Computed TomographyIncisorRegenerative EndodonticsRoot Canal TherapyAdolescentFemaleHumansMaleMaxillaRetreatmentTreatment OutcomeCone-Beam Computed TomographyPlatelet-Rich FibrinRegenerative Endodontics

Identifiers

PMID40319119
PMCPMC12049306

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.