ArticleScientific data2025
Comprehensive visceral transcriptome profiling of three pig breeds along altitudinal gradients in Yunnan.
Article in Scientific data, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Dynamic SOX2 gene expression revealed by phase-separated single RNA imaging in live porcine cells.The Journal of biological chemistry · 2026Article
- Alternative splicing and polyadenylation facilitate transcriptome diversity underlying high-altitude adaptation in pigs.Communications biology · 2026Article
- Full-length transcriptome atlas of porcine skeletal muscle reveals isoform-resolved genetic regulatory mechanisms for muscle growth.BMC genomics · 2026Article
- The c.64 + 2 T > A Founder Variant Hits Home: Report on 14 Patients Expands the Phenotypic Landscape of Inherited ARPC1B Deficiency - a Comparative Analysis.Clinical reviews in allergy & immunology · 2025Article
- Comprehensive visceral transcriptome profiling of three pig breeds along altitudinal gradients in Yunnan.Scientific data · 2025Article
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Authors and funding
17 authors.
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Abstract
High-altitude hypoxia acclimatization requires comprehensive physiological regulation in highland immigrants, yet the genetic mechanisms remain unclear. Yunnan's vertical zoning with pig breeds distributed across varying elevations provides an excellent model for investigating hypoxic adaptation. Here, we examined three indigenous Yunnan pig breeds: Diannan small-ear pigs (DSE, 500 m), Baoshan pigs (BS, 1500 m), and Diqing Tibetan pigs (DT, 3200 m). Using PacBio Iso-Seq, we obtained comprehensive full-length transcriptomes from five tissues (heart, kidney, liver, lung, and spleen), identifying 51,774 transcripts, including 34,813 novel ones, 74,843 Alternative Splicing (AS) events across 10,686 AS genes and pinpointed five actin-binding genes through weighted gene co-expression network analysis (WGCNA). Our research significantly improved porcine genome annotation and provided a high-quality transcriptome resource for investigating the genetic mechanisms of high-altitude hypoxia adaptation. This work lays a solid foundation for future studies in genetics, evolutionary biology, and environmental adaptation.
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