ArticleNature communications2025
Limited cell-autonomous anticancer mechanisms in long-lived bats.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Chiropteran (Animals : an open access journal from MDPI · 2026Article
- Molecular evolution of animal aging.The EMBO journal · 2026Review
- Beyond Mice and Men: Alternative Vertebrate and Invertebrate Models in Cancer Biology.Annual review of cancer biology · 2026Article
- Emerging technologies for advancing molecular and cellular research in bats.Zoological research · 2026Review
- Thinking outside the mouse: emerging vertebrate models in biomedicine.Biology open · 2026Article
- Short- and long-term costs of reproduction revealed by telomere dynamics in wild greater horseshoe bats.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Endogenous retroviruses in aging and cancer: from genomic defense to oncogenic activation.Mobile DNA · 2025Review
- Unlocking longevity through the comparative biology of aging.Nature aging · 2025Review
- Beyond the usual suspects: expanding aging research from classic models to really cool critters.Genes & development · 2025Review
- From Development to Regeneration: Insights into Flight Muscle Adaptations from Bat Muscle Cell Lines.Cells · 2025Article
- Establishment of a cell line from the hematophagous Bat Desmodus rotundus susceptible to Lyssavirus rabies.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Peto's paradox's relevance is off the scale.Aging · 2025Article
- Sex Differences in Telomere Length in a Bat With Female-Biased Longevity.Ecology and evolution · 2025Article
- Bat Ecology and Microbiome of the Gut: A Narrative Review of Associated Potentials in Emerging and Zoonotic Diseases.Animals : an open access journal from MDPI · 2024Review
- A Breakthrough on Modeling Cancer Prevention and Elimination by Low Radiation Doses.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
Several bat species live >20-40 years, suggesting that they possess efficient anti-aging and anti-cancer defenses. Here we investigate the requirements for malignant transformation in primary fibroblasts from four bat species Myotis lucifugus, Eptesicus fuscus, Eonycteris spelaea, and Artibeus jamaicensis - spanning the bat evolutionary tree and including the longest-lived genera. We show that bat fibroblasts do not undergo replicative senescence, express active telomerase, and show attenuated SIPs with dampened secretory phenotype. Unexpectedly, unlike other long-lived mammals, bat fibroblasts are readily transformed by two oncogenic "hits": inactivation of p53 or pRb and activation of HRAS
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.