ArticleNature communications2025
Hippocampal-entorhinal cognitive maps and cortical motor system represent action plans and their outcomes.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Article
- Categorization is 'baked' into the brain.Nature reviews. Neuroscience · 2026Review
- The effects of task similarity during representation learning in brains and neural networks.Nature communications · 2025Article
- Theta-nested gamma oscillations balance prediction and vigilance in spatial navigation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- fMRI signals of pattern separation in the neocortex and hippocampus to non-meaningful objects and their spatial location.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Efficiently interacting with the environment requires weighing and selecting among multiple alternative actions based on their associated outcomes. However, the neural mechanisms underlying these processes are still debated. We show that forming relations between arbitrary action-outcome associations involve building a cognitive map. Using an immersive virtual reality paradigm, participants learned 2D abstract motor action-outcome associations and later compared action combinations while their brain activity was monitored with fMRI. We observe a hexadirectional modulation of the activity in entorhinal cortex while participants compared different action plans. Furthermore, hippocampal activity scales with the 2D similarity between outcomes of these action plans. Conversely, the supplementary motor area represents individual actions, showing a stronger response to overlapping action plans. Crucially, the connectivity between hippocampus and supplementary motor area is modulated by the similarity between the action plans, suggesting their complementary roles in action evaluation. These findings provide evidence for the role of cognitive maps in action selection, challenging classical models of memory taxonomy and its neural bases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.