Trial reportBritish journal of anaesthesia2026
Continuous versus bolus norepinephrine administration to treat hypotension after induction of general anaesthesia in low-to-moderate risk noncardiac surgery patients: a randomised trial.
Trial report in British journal of anaesthesia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Preemptive noradrenaline infusion: a game-changer against post-induction hypotension in surgical sepsis: a randomized double blind trial.BMC anesthesiology · 2026Trial
- Continuous versus bolus norepinephrine administration and arterial blood pressure stability during induction of general anaesthesia in high-risk noncardiac surgery patients: a randomised trial.British journal of anaesthesia · 2025Trial
- Article
- Local adoption of norepinephrine as the first-line vasopressor in major noncardiac surgery: impact of a pragmatic clinical trial on real-world practice.British journal of anaesthesia · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypotension after induction of general anaesthesia (postinduction hypotension) is common in patients undergoing noncardiac surgery and frequently requires treatment with vasopressors such as norepinephrine. We tested the hypothesis that giving norepinephrine continuously using a syringe infusion pump, compared with giving it as repeated manual boluses, reduces postinduction hypotension within 15 min after starting induction of general anaesthesia in low-to-moderate risk noncardiac surgery patients.
methodsPatients undergoing elective noncardiac surgery were randomised to either continuous norepinephrine infusion or manual bolus norepinephrine administration intravenously during induction of general anaesthesia. In both groups, norepinephrine was administered through a peripheral venous catheter. Blood pressure was measured by clinicians using intermittent oscillometry. We additionally performed blinded continuous noninvasive blood pressure monitoring to quantify the duration and extent of postinduction hypotension. The primary endpoint was postinduction hypotension, defined as the area under a MAP of 65 mm Hg within 15 min after starting induction of general anaesthesia.
resultsFrom 276 randomised patients, 261 had complete data (median age: 62 yr; 40% female). The median (25th-75th percentile) area under a MAP of 65 mm Hg was 3.6 (0.0-16.6) mm Hg × min in patients assigned to continuous norepinephrine infusion, compared with 5.5 (0.5-24.5) mm Hg × min in patients assigned to manual bolus norepinephrine administration (P=0.070). The median duration of MAP values <65 mm Hg was 1.0 (0.0-2.5) min vs 1.4 (0.2-3.2) min (P=0.052).
conclusionsContinuous administration of norepinephrine, compared with repeated manual bolus doses, did not reduce postinduction hypotension in low-to-moderate risk noncardiac surgery patients who had intermittent oscillometric blood pressure monitoring.
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