Evidence map›Paper›PMID 40318802›Full record

ArticleNeurobiology of learning and memory2025

Assessing the role of BNST GABA neurons in backward conditioned suppression.

Annie Ly, Hayden Hotchkiss, Emily D Prévost, Julianne M Pelletier, Melissa A Deming, Luma Murib, David H Root

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of learning and memory, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Annie LyDepartment of Psychology and Neuroscience, University of Colorado Boulder, 2860 Wilderness Pl, Boulder, CO 80301, USA.
Hayden HotchkissDepartment of Psychology and Neuroscience, University of Colorado Boulder, 2860 Wilderness Pl, Boulder, CO 80301, USA.
Emily D PrévostDepartment of Psychology and Neuroscience, University of Colorado Boulder, 2860 Wilderness Pl, Boulder, CO 80301, USA.
Julianne M PelletierDepartment of Psychology and Neuroscience, University of Colorado Boulder, 2860 Wilderness Pl, Boulder, CO 80301, USA.
Melissa A DemingDepartment of Psychology and Neuroscience, University of Colorado Boulder, 2860 Wilderness Pl, Boulder, CO 80301, USA.
Luma MuribDepartment of Psychology and Neuroscience, University of Colorado Boulder, 2860 Wilderness Pl, Boulder, CO 80301, USA.
David H RootDepartment of Psychology and Neuroscience, University of Colorado Boulder, 2860 Wilderness Pl, Boulder, CO 80301, USA. Electronic address: David.Root@Colorado.edu.

Funding

Regulation and functional contribution of hypothalamic modified adult hippocampal neurogenesisR01MH132222 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SONG, JUAN · 2023 to 2025
$2.3M
Genetic dissection of ventral tegmental area glutamate and GABA neurons in reward and aversionR01DA047443 · NIDA · UNIVERSITY OF COLORADO · PI ROOT, DAVID H · 2020 to 2024
$1.7M
Circuits and neurotransmitters involved in VTA glutamate neuron regulation of the consequences of stressR01MH130576 · NIMH · UNIVERSITY OF COLORADO · PI MICHAEL V BARATTA, David H Root · 2024 to 2026
$1.4M
NIDA NIH HHS R01 DA047443NIMH NIH HHS R01 MH130576NIMH NIH HHS R01 MH132222
6 · The paper itself

Abstract

Conditioned suppression is a useful paradigm for measuring learned avoidance. In most conditioned suppression studies, forward conditioning is used where a cue predicts an aversive stimulus. However, backward conditioning, in which an aversive stimulus predicts a cue, provides unique insights into learned avoidance due to its influence on both conditioned excitation and inhibition. We trained mice to consume sucrose in context A, associated an aversive stimulus in context B to few or many forward or backwards paired cues (CS + ), and then tested for conditioned suppression in context A in response to the CS + . We found that few or many forward CS + and few backward CS + produced conditioned suppression, but many backwards cues did not. Administration of diazepam, a positive allosteric modulator of the GABA

Indexed as

Avoidance LearningConditioning, ClassicalGABAergic NeuronsAnimalsCuesDiazepamGABA ModulatorsMaleMiceMice, Inbred C57BLReceptors, GABA-ADiazepamGABA ModulatorsReceptors, GABA-AAnxietyBackward conditioningDiazepamFearForward conditioningLearning

Identifiers

PMID40318802
PMCPMC12699952

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.