Evidence map›Paper›PMID 40318638›Full record

ArticleCell reports2025

Genetic and training adaptations in the Haenyeo divers of Jeju, Korea.

Diana Aguilar-Gómez, Jacob Bejder, Jonathan Graae, Yelin Ko, Andrew Vaughn, Kendell Clement, Martin Tristani-Firouzi, Joo-Young Lee, Nikolai B Nordsborg, Rasmus Nielsen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Advances in breath-hold diving research: a state-of-the-art review.European journal of applied physiology · 2026
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Diana Aguilar-GómezEcology and Evolutionary Biology, University of California, Los Angeles, 612 Charles E. Young Drive South, Los Angeles, CA 90095, USA; Center for Computational Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Jacob BejderDepartment of Nutrition, Exercise, and Sports, University of Copenhagen, Nørre Allé 51, 2200 Copenhagen, Denmark.
Jonathan GraaeDepartment of Nutrition, Exercise, and Sports, University of Copenhagen, Nørre Allé 51, 2200 Copenhagen, Denmark.
Yelin KoDepartment of Human-Centered Design, Cornell University, Ithaca, NY 14850, USA.
Andrew VaughnCenter for Computational Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Kendell ClementDepartment of Biomedical Informatics, University of Utah, 421 Wakara Way #140, Salt Lake City, UT 84108, USA.
Martin Tristani-FirouziDivision of Pediatric Cardiology, Department of Pediatrics, University of Utah, 81 Mario Capecchi Dr., Salt Lake City, UT, USA; Nora Eccles Harrison CVRTI Cardiovascular Research Training Institute, University of Utah, Salt Lake City, UT, USA.
Joo-Young LeeResearch Institute for Human Ecology, College of Human Ecology, Seoul National University, Seoul 08826, Republic of Korea; Graphene Research Center for Convergence Technology, Advanced Institute of Convergence Technology, Suwon 16229, Republic of Korea.
Nikolai B NordsborgDepartment of Nutrition, Exercise, and Sports, University of Copenhagen, Nørre Allé 51, 2200 Copenhagen, Denmark.
Rasmus NielsenCenter for Computational Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Melissa IlardoDepartment of Biomedical Informatics, University of Utah, 421 Wakara Way #140, Salt Lake City, UT 84108, USA; Nora Eccles Harrison CVRTI Cardiovascular Research Training Institute, University of Utah, Salt Lake City, UT, USA. Electronic address: melissa.ilardo@utah.edu.

Funding

Enabling Precision Genomics Using Adaptive VariationR01GM138634 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI NIELSEN, RASMUS · 2020 to 2023
$1.7M
Inference and application of graphs for genomic dataR35GM153400 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI RASMUS NIELSEN · 2024 to 2026
$1.3M
Pan-disease characterization of DNA methylation dysregulationR00HG011658 · NHGRI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI CLEMENT, KENDELL · 2023 to 2025
$747k
NHGRI NIH HHS R00 HG011658NIGMS NIH HHS R01 GM138634NIGMS NIH HHS R35 GM153400
6 · The paper itself

Abstract

Natural selection and relative isolation have shaped the genetics and physiology of unique human populations from Greenland to Tibet. Another such population is the Haenyeo, the all-female Korean divers renowned for their remarkable diving abilities in frigid waters. Apnea diving induces considerable physiological strain, particularly in females diving throughout pregnancy. In this study, we explore the hypothesis that breath-hold diving has shaped physiological and genetic traits in the Haenyeo. We identified pronounced bradycardia during diving, a likely training effect. We paired natural selection and genetic association analyses to investigate adaptive genetic variation that may mitigate the effects of diving on pregnancy through an associated reduction of diastolic blood pressure. Finally, we identified positively selected variation in a gene previously associated with cold water tolerance, which may contribute to reduced hypothermia susceptibility. These findings highlight the importance of traditional diving populations for understanding genetic and physiological adaptation.

Indexed as

Adaptation, PhysiologicalDivingAdultBlood PressureFemaleHumansPregnancyRepublic of KoreaSelection, Geneticbreath-hold divingcardiovascular physiologyCP: Genomicsevolutionary adaptationnatural selection

Identifiers

PMID40318638
PMCPMC12129667

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.