Evidence map›Paper›PMID 40318631›Full record

ArticleImmunity2025

A hierarchy of intestinal antigens instructs the CD4

Jaeu Yi, Jisun Jung, David Horton, Patricia Hsieh, Yangqing Peng, Sean J Wang, Rodney Newberry, Aaron C Ericsson, Kwang Soon Kim, Andrew L Kau and 1 more

Abstract read
In one paragraph

Article in Immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Intestinal uptake regulates T cell responses to dietary antigens.bioRxiv : the preprint server for biology · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jaeu YiDepartment of Internal Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Biological Science, Ajou University, Suwon 16499, Republic of Korea.
Jisun JungDepartment of Internal Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO 63110, USA.
David HortonDepartment of Internal Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Patricia HsiehDepartment of Internal Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Yangqing PengDepartment of Internal Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Sean J WangDepartment of Internal Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Rodney NewberryDepartment of Internal Medicine, Division of Gastroenterology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Aaron C EricssonThe Mutant Mouse Resource and Research Center, University of Missouri (MU-MMRRC), Columbia, MO 65201, USA.
Kwang Soon KimDepartment of Life Sciences, Pohang University of Science and Technology, Pohang 37673, Republic of Korea.
Andrew L KauDivision of Allergy and Immunology, Department of Medicine and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
Chyi-Song HsiehDepartment of Internal Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: chsieh@wustl.edu.

Funding

Washington University Rheumatic DiseasesResearch Resource-based CenterP30AR073752 · NIAMS · WASHINGTON UNIVERSITY · PI Christine T. Pham · 2018 to 2026
$7.6M
Harnessing Antibody Responses to Prevent and Treat Urinary Tract InfectionsR01AI165915 · NIAID · WASHINGTON UNIVERSITY · PI Andrew Leon Kau · 2022 to 2026
$3.1M
Immune interactions with commensal microbes in early lifeR01AI173220 · NIAID · WASHINGTON UNIVERSITY · PI CHYI S HSIEH, Rodney D Newberry · 2023 to 2026
$2.8M
Gut Intrinsic Inflammatory ResponsesU01AI163073 · NIAID · WASHINGTON UNIVERSITY · PI HSIEH, CHYI S, NEWBERRY, RODNEY D · 2021 to 2025
$2.6M
NIAID NIH HHS R01 AI165915NIAID NIH HHS R01 AI173220NIAID NIH HHS U01 AI163073NIAMS NIH HHS P30 AR073752
6 · The paper itself

Abstract

Intestinal CD4

Indexed as

AntigensCD4-Positive T-LymphocytesGastrointestinal MicrobiomeInflammatory Bowel DiseasesIntestinal MucosaIntestinesReceptors, Antigen, T-CellReceptors, Antigen, T-Cell, alpha-betaAnimalsColitisDisease Models, AnimalMiceMice, Inbred C57BLMice, TransgenicAntigensReceptors, Antigen, T-CellReceptors, Antigen, T-Cell, alpha-betaCD4(+) T cell responses to self-, diet, and microbial antigenshierarchical TCR classificationinflammatory bowel diseaseintestinal CD4(+) T cell responsesmacro- and micro-immunologic CD4(+) T cell responsenetwork analysis of TCR and microbe 16S sequences

Identifiers

PMID40318631
PMCPMC12225692

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.