Evidence map›Paper›PMID 40318538›Full record

ArticleJournal of psychiatric research2025

A cohort study of predictors of short-term nonfatal suicidal and self-harm events among individuals with mental health disorders treated in the emergency department.

Steven C Marcus, Sara Wiesel Cullen, Timothy Schmutte, Ming Xie, Tony Liu, Lyle H Ungar, Nicholas C Cardamone, Nathaniel J Williams, Mark Olfson

Abstract read
In one paragraph

Article in Journal of psychiatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Steven C MarcusSchool of Social Policy & Practice, University of Pennsylvania, Philadelphia, PA, USA.
Sara Wiesel CullenSchool of Social Policy & Practice, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: swiesel@upenn.edu.
Timothy SchmutteDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Ming XieDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Tony LiuDepartment of Computer Science, Mount Holyoke College, South Hadley, MA, USA.
Lyle H UngarDepartment of Computer and Information Science, University of Pennsylvania, Philadelphia, PA, USA.
Nicholas C CardamoneDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Nathaniel J WilliamsSchool of Social Work, Boise State University, Boise, ID, USA.
Mark OlfsonDepartment of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University and the New York State Psychiatric Institute, New York, NY, USA.

Funding

Development and clinical interpretation of machine learning emergency department suicide prediction algorithms using electronic health records and claimsR01MH126895 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI MARCUS, STEVEN C, OLFSON, MARK · 2021 to 2024
$3.3M
NIMH NIH HHS R01 MH126895
6 · The paper itself

Abstract

backgroundPatients presenting to emergency departments (EDs) for mental health problems have an elevated short-term risk of repeat ED visits, subsequent hospitalization, and suicide.

objectiveUse health records to identify predictors of nonfatal suicidal or self-harm events following emergency department visits of individuals with mental health disorders.

methodsElectronic health record data from 2015 to 2022 were used to identify ED visits with mental health diagnoses for individuals 10 and older; extract 408 potential predictors including demographic, historical and baseline clinical characteristics from structured and unstructured data; and subsequent suicidal and self-harm events. We constructed a series of progressively additive logistic regression and gradient tree boosting (GTB) models to evaluate how groups of clinical features influenced likelihood of a nonfatal event 180-days after an ED visit.

resultsRecords identified 2,445,597 ED episodes and 176,000 subsequent suicidal or self-harm events within 180-days. Individuals experiencing an event relative to those without an event were less likely to be > 65 (3.6 % vs 16.7 %; h = 0.46), more likely to be male (55.7 % vs 40.8 %; h = 0.30) and covered by Medicaid (61.5 % vs 42.2 %, h = 0.39). The final model with 408 clinical features resulted in an AUC of 0.851 (logistic regression) and 0.863 (GTB). Diagnoses of bulimia nervosa (OR = 1.84, p < .0001) and cutting (OR = 2.62, p < .0001) were most highly associated with any subsequent event and suicidal self-harm, respectively.

conclusionMachine learning algorithms effectively predicted nonfatal suicide-related events within six months following ED visits among individuals with mental health disorders highlighting the importance of suicide symptom focused assessment and prevention efforts during routine emergency mental healthcare, particularly for patients with bulimia nervosa.

Indexed as

Emergency Service, HospitalMental DisordersSelf-Injurious BehaviorSuicideAdolescentAdultAgedCohort StudiesElectronic Health RecordsFemaleHumansMaleMiddle AgedSuicidal IdeationYoung AdultEmergency departmentMental healthSuicide prevention

Identifiers

PMID40318538
PMCPMC13150847

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.