Evidence map›Paper›PMID 40318302›Full record

ArticleRedox biology2025

Defective protein persulfidation is involved in obesity associated skeletal muscle dysfunction: role of SIRT-1.

M Smimmo, V Casale, D D'Andrea, I Bello, N Iaccarino, F Romano, V Brancaleone, E Panza, R d'Emmanuele di Villa Bianca, A Katsouda and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

M SmimmoDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.
V CasaleDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.
D D'AndreaSchool of Molecular Biosciences, University of Glasgow, UK; Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V. Dortmund, Germany.
I BelloDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.
N IaccarinoDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.
F RomanoDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.
V BrancaleoneDepartment of Science, University of Potenza, Basilicata, Italy.
E PanzaDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.
R d'Emmanuele di Villa BiancaDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.
A KatsoudaClinical, Experimental Surgery and Translational Research Center, Biomedical Research Foundation of the Academy of Athens, Athens, Greece; Laboratory of Pharmacology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.
E MitidieriDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.
I AntoniadouClinical, Experimental Surgery and Translational Research Center, Biomedical Research Foundation of the Academy of Athens, Athens, Greece; Laboratory of Pharmacology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.
A PapapetropoulosClinical, Experimental Surgery and Translational Research Center, Biomedical Research Foundation of the Academy of Athens, Athens, Greece; Laboratory of Pharmacology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.
F MaioneDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.
S CastaldoU.O.C. Ricerca Formazione & Cooperazione Internazionale, A.O.R.N." Antonio Cardarelli", Naples, Italy.
M FriuliDepartment of Physiology and Pharmacology 'V. Erspamer', Sapienza University of Rome, Rome, Italy.
A RomanoDepartment of Physiology and Pharmacology 'V. Erspamer', Sapienza University of Rome, Rome, Italy.
S GaetaniDepartment of Physiology and Pharmacology 'V. Erspamer', Sapienza University of Rome, Rome, Italy.
R SorrentinoDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.
A RandazzoDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.
G CirinoDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.
M BucciDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy. Electronic address: mrbucci@unina.it.
M FilipovicSchool of Molecular Biosciences, University of Glasgow, UK; Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V. Dortmund, Germany.
V VelleccoDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ectopic fat deposition in skeletal muscle (SKM) due to obesity leads to biochemical and morphological alterations that deteriorate SKM quality and performance. Here, we show that impaired MPST-derived hydrogen sulfide (H

Indexed as

Muscle, SkeletalObesitySirtuin 1AnimalsDisease Models, AnimalHumansHydrogen SulfideMaleMiceMice, KnockoutSignal TransductionHydrogen SulfideSirt1 protein, mouseSirtuin 1Db/db miceH(2)S donorsPersulfidationSkeletal muscleSodium palmitate

Identifiers

PMID40318302
PMCPMC12124727

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.