ReviewJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2025
Functions of secretory calcium-binding phosphoproteins in dental mineralization.
Review in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Root Cementum Molecular Structure and Its Role in Maintaining Oral Health-Systematic Review.International journal of molecular sciences · 2025Pooled it
- SCPP Gene Repertoires in Teleosts and Evolutionary Changes in Bone, Teeth, and Scales.Genome biology and evolution · 2026Article
- Mammalian Osteoderm Ultrastructure in the Armored Acomys Spiny Mouse Tail.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Article
- Genetic reduction or deletion of osteopontin in osteomalacicJBMR plus · 2025Article
- DSP and DPP are dispensable for initiation of dentin and enamel mineralization but critical for circumpulpal dentin mineralization.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Biomineralization of skeletal and dental tissues has evolved via a suite of regulatory extracellular matrix proteins. The secretory calcium-binding phosphoproteins (SCPPs) are encoded by genes that arose by duplication. In the human genome, 23 SCPP genes have been identified, and 2 groups of SCPPs regulate dental mineralization: bone, dentin, and/or cementum matrix proteins and enamel proteins. In the past 2 decades, the functional roles of SCPPs in dental mineralization have been revealed by studies of human disorders and genetically edited mice. Five enamel SCPPs, amelogenin (AMEL), enamelin (ENAM), ameloblastin (AMBN), odontogenic ameloblast associated (ODAM), and amelotin (AMTN), are secreted by ameloblasts during sequentially arranged stages of amelogenesis. Sequence variants in 4 of the enamel SCPP genes (AMEL, ENAM, AMBN, and AMTN) have been associated with inherited malformations of enamel, termed amelogenesis imperfecta. Loss-of-function variants contribute to enamel of reduced thickness and/or mineral density. Two bone/dentin/cementum SCPPs, dentin matrix protein 1 and dentin sialophosphoprotein (DSPP), are critical for dentin mineralization. Functional studies in genetically edited mice imply that dentin sialoprotein (the N-terminal fragment of DSPP) promotes the propagation of mineralization, and that dentin phosphoprotein (the C-terminal fragment of DSPP) is essential for the fusion and the increase of mineral density of calcospherites. Pathogenic variants in DSPP can cause 2 distinct entities of isolated hereditary dentinogenesis imperfecta. Bone sialoprotein (BSP) and osteopontin are markers of cementum (and bone) in multiple species. Global ablation of BSP in mice resulted in acellular cementum hypoplasia, hypomineralized alveolar bone and breakdown of periodontal function. Osteopontin appears to have a more complex role in regulating mineralized tissues via several direct and indirect mechanisms. Research into SCPPs has provided new insights into the evolution of biomineralization, normal dental development, and inherited disorders, as well as translational directions for tissue repair and regeneration.
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