Evidence map›Paper›PMID 40318105›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Charge Relocation Enables a Modular and Diastereoselective Synthesis of cis-Substituted Tetrahydrofurans.

Zhi-Jie Niu, Bogdan R Brutiu, Margaux Riomet, Daniel Kaiser, Nuno Maulide

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Diastereoselective Synthesis ofACS catalysis · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhi-Jie NiuInstitute of Organic Chemistry, University of Vienna, Währinger Straße 38, Vienna, 1090, Austria.
Bogdan R BrutiuInstitute of Organic Chemistry, University of Vienna, Währinger Straße 38, Vienna, 1090, Austria.
Margaux RiometInstitute of Organic Chemistry, University of Vienna, Währinger Straße 38, Vienna, 1090, Austria.
Daniel KaiserInstitute of Organic Chemistry, University of Vienna, Währinger Straße 38, Vienna, 1090, Austria.
Nuno MaulideInstitute of Organic Chemistry, University of Vienna, Währinger Straße 38, Vienna, 1090, Austria.

Funding

Austrian Science Fund 10.55776/P37182ERC ERC-2023-ADG 101142915 C-HANCE
6 · The paper itself

Abstract

Diastereoselective construction of organic scaffolds from simple and commercial materials is a powerful strategy in contemporary organic synthesis. Herein, we report a novel disconnection for the direct preparation of tetrahydrofurans (THFs) and corresponding derivatives from acyl chlorides and alkenes using charge relocation. Newly synthesised Hantzsch ester derivatives, functioning both as hydride sources and selectivity modulators, enabled exceptional diastereoselectivity. The wide range of alkenes tolerated is a highlight of the method, enabling the construction of structurally distinct THF-containing skeletons.

Indexed as

Charge relocationDiastereoselectivityHantzsch estersOxocarbenium ionsTetrahydrofurans

Identifiers

PMID40318105
PMCPMC12258665

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.