Trial reportCancer medicine2025
Chidamide, a Histone Deacetylase Inhibitor, Combined With R-GemOx in Relapsed/Refractory Diffuse Large B-Cell Lymphoma (TRUST): A Multicenter, Single-Arm, Phase 2 Trial.
Trial report in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04022005 (Chidamide Combined With R-GemOx), which is not on this map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Chidamide Combined With R-GemOx(Rituximab、Gemcitabine Plus Oxaliplatin) Regimen as Salvage Treatment for Transplant-ineligible Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma: a Multi-center, Single Arm, Phase II Study
Who cites it
6 citing papers in PubMed.
- Targeting signaling pathways in lymphoma: From molecular mechanisms to clinical breakthroughs.Chinese medical journal · 2026Review
- Histone deacetylases: Function in tumor development and therapeutic prospects (Review).Oncology letters · 2026Review
- Synergistic effects of HDAC inhibitor tucidinostat and ENT inhibitor dipyridamole in T-cell malignancies.Scientific reports · 2026Article
- Case Report: Surgical resection combined with chemotherapy for a primary cardiac lymphoma involving right heart structures.Frontiers in oncology · 2026Article
- Mechanisms of first-line treatment resistance in diffuse large B-cell lymphoma.Frontiers in immunology · 2026Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors.
Funding
Abstract
backgroundHistone deacetylase (HDAC) inhibitors demonstrated a synergistic anti-tumor effect with rituximab and chemotherapy in preclinical studies on diffuse large B-cell lymphoma (DLBCL). This phase 2 trial aimed to evaluate the efficacy and safety of chidamide, an orally active HDAC inhibitor, plus the R-GemOx regimen for relapsed/refractory (R/R) DLBCL.
methodsPatients with transplantation-ineligible R/R DLBCL received chidamide (20 mg, oral, days 1, 4, 8, 11, 15, and 18), rituximab (375 mg/m
resultsBetween June 19, 2019 and July 5, 2022, 54 patients were enrolled. The ORR was 59.3% (95% CI: 45.0-72.4). With a median follow-up of 38.1 months (interquartile range: 19.5-48.2), the median progression-free survival and overall survival were 7.4 (95% CI: 5.2-14.2) and 23.9 (95% CI: 15.2-not reached) months, respectively. The most common grade 3/4 treatment-emergent adverse events (TEAEs) were neutropenia (40.7%), thrombocytopenia (33.3%), and leukopenia (27.8%). Whole-exome sequencing showed that CREBBP mutations and BTG2 mutations were associated with poor response and survival.
conclusionChidamide plus R-GemOx demonstrated promising anti-tumor activity with acceptable toxicities in transplantation-ineligible R/R DLBCL patients. Patients with CREBBP mutations and BTG2 mutations had inferior response and survival.
trial registrationClinicalTrials.gov identifier: NCT04022005.
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