ArticleJournal of veterinary internal medicine
Longitudinal Study of Renal Health Screening in Apparently Healthy Aging Dogs.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Transforming growth factor-β in kidney disease in dogs and cats: a review of the evidence of its role in renal fibrosis.Journal of veterinary internal medicine · 2026Review
- Serum Cystatin C and the Urinary NAG Index Identify an Altered Renal Biochemical Phenotype in Clinically Healthy Geriatric Dogs with Normal Serum Creatinine: A Three-Tier Cross-Sectional Study.Veterinary sciences · 2026Article
- Urinary neutrophil gelatinase-associated lipocalin in dogs: accuracy of a novel rapid test and biomarker behavior across clinical settings.Journal of veterinary internal medicine · 2026Article
- Chronic renal disease detection developments with future potential to improve veterinary clinical practice.Frontiers in veterinary science · 2026Review
- Exploring the Importance of Repeated Health Screening in Healthy Older Dogs.Journal of veterinary internal medicineArticle
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCombined measurement of functional, glomerular, and tubular markers in aging dogs is essential to detect early renal disease.
objectivesProspective longitudinal study to describe renal function and assess which biomarkers are associated with the development of early renal disease or death. ANIMALS: One hundred and twenty-two apparently healthy senior and geriatric dogs.
methodsProspective longitudinal study. Renal function was evaluated at baseline (T0) and every 6-12 months over 2 years, using systolic blood pressure measurements (SBP) and validated serum (creatinine, symmetric dimethylarginine, cystatin C [sCysC]), and urinary (specific gravity [USG], protein:creatinine [UPC], albumin:creatinine, retinol-binding protein:creatinine [uRBPcr]) biomarkers. Glomerular filtration rate (GFR) was measured in a subgroup. Survival models were used to assess the predictive value of measured biomarkers at baseline for the onset of azotemic chronic kidney disease (CKD) or death, respectively.
resultsA total of 122 dogs were included; follow-up was available in 106 (T12) and 92 (T24); and GFR was estimated in 18 (T0), 11 (T12), and 10 (T24) dogs. Throughout the study, 15/122 (12%) dogs showed evidence of non-azotemic CKD, and in 11/106 (10%) dogs, azotemic CKD developed. Proteinuria was not associated with azotemic CKD, in contrast to muscle condition score, functional markers, and uRBPcr. Death was weakly associated with USG, UPC, and sCysC. CONCLUSIONS AND CLINICAL IMPORTANCE: Over a 2-year period, 20% (26/122) of older dogs developed CKD, mostly persistent renal proteinuria (15/122). Muscle wasting and functional markers combined with uRBPcr had the best predictive value for the onset of azotemic CKD in these older, previously apparently healthy dogs.
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