Evidence map›Paper›PMID 40317912›Full record

ArticleAdvanced healthcare materials2025

Biohybrid Vascular Graft Made of Textile-Reinforced Elastin-Like Recombinamers and Its Preservation via Drying Processes.

Dominic Pascal Andre, Stephan Ruetten, José Carlos Rodríguez-Cabello, Stefan Jockenhoevel, Thomas Schmitz-Rode, Alicia Fernández-Colino

Abstract read
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dominic Pascal AndreDepartment of Biohybrid and Medical Textiles (BioTex), AME-Institute of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University, 52074, Aachen, Germany.
Stephan RuettenElectron Microscopy Facility, Uniklinik RWTH Aachen, 52074, Aachen, Germany.
José Carlos Rodríguez-CabelloBioforge Lab, Group for Advanced Materials and Nanobiotechnology, Biomedical Networking Research Center of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Edificio LUCIA, Universidad de Valladolid, Valladolid, 47011, Spain.
Stefan JockenhoevelDepartment of Biohybrid and Medical Textiles (BioTex), AME-Institute of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University, 52074, Aachen, Germany.
Thomas Schmitz-RodeAME-Institute of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University, 52074, Aachen, Germany.
Alicia Fernández-ColinoDepartment of Biohybrid and Medical Textiles (BioTex), AME-Institute of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University, 52074, Aachen, Germany.ORCID 0000-0003-2096-3464

Funding

Bundesministerium für Bildung und Forschung 13GW0452A-CBundesministerium für Bildung und Forschung 13XP5136Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y LeónDeutsche Forschungsgemeinschaft 495328185Junta de Castilla y León VA188P23Ministerio de Ciencia e Innovación and European Regional Development Fund PID2022-137484OB-I00
6 · The paper itself

Abstract

Vascular grafts are crucial for treating cardiovascular diseases and providing vascular access for hemodialysis in end-stage renal disease, conditions that affect millions of people globally. To address the persisting clinical need for better therapy for these conditions, new designs involving novel materials and innovative tissue-engineered approaches are being developed. Successful clinical translation of such designs will require to ensure device safety, particularly sterility and mechanical integrity. The prevailing method for ensuring sterility is ethylene oxide sterilization, which requires a dry product. The challenge of drying biohybrid implants is substantial, as they contain multiple components (e.g., textile and hydrogel) with differing properties. To address this open question, the effects of different drying methods on the morphological and mechanical properties of biohybrid implants made from elastin-like recombinamers (ELRs) are investigated. For that, mechanical characteristics defined in ISO 7198, as well as the cell attachment behavior on biohybrid vascular grafts, treated either with lyophilization (LYO) or CO

Indexed as

Blood Vessel ProsthesisDesiccationElastinTextilesCell AdhesionFreeze DryingHumansTissue EngineeringTissue ScaffoldsElastindryingengineered elastintextiletranslationvascular graft

Identifiers

PMID40317912
PMCPMC12147985

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.