Evidence map›Paper›PMID 40317897›Full record

ArticleJournal of biomedical materials research. Part B, Applied biomaterials2025

One-Pot Synthesis of Antibacterial and Antioxidant Self-Healing Bioadhesives Using Ugi Four-Component Reactions.

Ronak Afshari, Arpita Roy, Saumya Jain, Kaimana Lum, Joyce Huang, Sam Denton, Nasim Annabi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomedical materials research. Part B, Applied biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ronak AfshariDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, California, USA.ORCID 0000-0003-4688-4406
Arpita RoyDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, California, USA.
Saumya JainDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, California, USA.
Kaimana LumDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, California, USA.
Joyce HuangDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, California, USA.
Sam DentonDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, California, USA.
Nasim AnnabiDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, California, USA.ORCID 0000-0003-1879-1202

Funding

Engineering highly elastic surgical sealants with hemostatic propertiesR01HL140618 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANNABI, NASIM, KHADEMHOSSEINI, ALI · 2018 to 2021
$2.8M
Engineering a naturally derived and highly adhesive surgical sealantR01EB023052 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANNABI, NASIM, KHADEMHOSSEINI, ALI · 2017 to 2022
$2.4M
NHLBI NIH HHS R01 HL140618NIBIB NIH HHS R01 EB023052NIH HHS R01-EB023052NIH HHS R01-HL140618
6 · The paper itself

Abstract

Bioadhesive materials are extensively utilized as alternatives to surgical sutures and wound dressings. Despite significant advancements in their synthesis, current bioadhesives suffer from inadequate mechanical stability, suboptimal wet tissue adhesion, and a lack of inherent antibacterial and antioxidant properties, while requiring multistep synthesis processes, complicating their production for biomedical applications. To address these limitations, we developed a new bioadhesive, named UgiGel, synthesized through a one-pot Ugi four-component reaction (Ugi-4CR). Our strategy utilized gelatin as the backbone, 4-formylphenylboronic acid (4-FPBA) as an aldehyde source for improved adhesion and antibacterial activity, gallic acid (GA) as a carboxylic acid source for improved antioxidant activity and wound healing, and cyclohexyl isocyanide (CyIso) to induce pseudopeptide structures. The internal crosslinking between GA and 4-FPBA via dynamic boronate ester bond formation, triggered by slight pH changes (7.4-7.8) and temperature elevation (25°C-40°C), resulted in the formation of viscoelastic and self-healing hydrogels with water as the only byproduct without the need for initiator/light activation. UgiGel showed higher adhesion to porcine skin tissue (139.8 ± 8.7 kPa) as compared to commercially available bioadhesives, Evicel (26.3 ± 2.6 kPa) and Coseal (19.3 ± 9.9 kPa). It also demonstrated effective antibacterial properties against both Gram-negative and Gram-positive bacteria, as well as antioxidant activity. Additionally, the in vitro studies using NIH-3T3 cells confirmed the biocompatibility of the UgiGel over 7 days of culture. Moreover, in vivo biocompatibility and biodegradation of UgiGel were confirmed via subcutaneous implantation in rats for up to 28 days. Our results demonstrated that UgiGel outperformed commercially available bioadhesives in terms of adhesion, self-healing, and antibacterial activity, without compromising biocompatibility or physical properties, representing a promising multifunctional bioadhesive for wound sealing and repair.

Indexed as

Anti-Bacterial AgentsAntioxidantsHydrogelsTissue AdhesivesWound HealingAnimalsBoronic AcidsGelatinMiceNIH 3T3 CellsSwineAnti-Bacterial AgentsAntioxidantsBoronic AcidsGelatinHydrogelsTissue Adhesivesadhesive hydrogelantibacterial propertyantioxidant propertyself‐healingUgi four‐component reactionviscoelasticitywound repair

Identifiers

PMID40317897
PMCPMC12356498

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.