Mapping Brain Lesions to Conduction Delays: The Next Step for Personalized Brain Models in Multiple Sclerosis.

Multiple sclerosis (MS) is a clinically heterogeneous, multifactorial autoimmune disorder affecting the central nervous system. Structural damage to the myelin sheath, resulting in the consequent slowing of the conduction velocities, is a key pathophysiological mechanism. In fact, the conduction velocities are closely related to the degree of myelination, with thicker myelin sheaths associated to higher conduction velocities. However, how the intensity of the structural lesions of the myelin translates to slowing of nerve conduction delays is not known. In this work, we use large-scale brain models and Bayesian model inversion to estimate how myelin lesions translate to longer conduction delays across the damaged tracts. A cohort of 38 subjects (20 healthy and 18 with MS) underwent MEG recordings during an eyes-closed resting-state condition, along with MRI acquisitions and detailed white matter tractography analysis. We observed that MS patients consistently showed decreased power within the alpha frequency band (8-13 Hz) as compared to the healthy group. We also derived a lesion matrix indicating the percentage of lesions for each tract in every patient. Using large-scale brain modeling, the neural activity of each region was represented as a Stuart-Landau oscillator operating in a regime showing damped oscillations, and the regions were coupled according to subject-specific connectomes. We propose a linear formulation to the relationship between the conduction delays and the amount of structural damage in each white matter tract. Dependent upon the parameter