Evidence map›Paper›PMID 40317719›Full record

ArticleAging2025

Defining the hypoxic thresholds that trigger blood-brain barrier disruption: the effect of age.

Arjun Sapkota, Sebok K Halder, Richard Milner

Abstract read
In one paragraph

Article in Aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Arjun SapkotaSan Diego Biomedical Research Institute, San Diego, CA 92121, USA.
Sebok K HalderSan Diego Biomedical Research Institute, San Diego, CA 92121, USA.
Richard MilnerSan Diego Biomedical Research Institute, San Diego, CA 92121, USA.

Funding

The protective role of microglia in preventing hypoxic disruption of blood-brain barrier integrity and VCIDRF1NS119477 · NINDS · SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE · PI MILNER, D. RICHARD · 2021 to 2021
$2.2M
The protective role of microglia in preventing hypoxic disruption of blood-brain barrier integrity and VCIDR01NS119477 · NINDS · SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE · PI MILNER, D. RICHARD · 2024 to 2025
$1.4M
NINDS NIH HHS R01 NS119477NINDS NIH HHS RF1 NS119477
6 · The paper itself

Abstract

Chronic mild hypoxia (CMH; 8% O

Indexed as

AgingBlood-Brain BarrierHypoxiaAnimalsCell ProliferationEndothelial CellsMaleMiceMice, Inbred C57BLblood-brain barrier integritychronic mild hypoxiaendothelialhypoxic thresholdmicrogliaproliferation

Identifiers

PMID40317719
PMCPMC12151515

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.