ArticleAging2025
Oxytocin modulates insulin and GLP-1 secretion in pancreatic islets.
Article in Aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Neuroendocrine regulation of adipose partitioning in polyendocrine metabolic ovarian syndrome: the gut-brain-adipose axis.Journal of endocrinological investigation · 2026Review
- Role of Oxytocin in Obesity.Current diabetes reports · 2026Review
- Inhibitory Effects of Oxytocin on Jejunal Migrating Myoelectric Complex Activity in Fasted Rats: Role of Oxytocin and GLP-1 Receptors.Life (Basel, Switzerland) · 2026Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveOxytocin (Oxt) is secreted to the peripheral body through the pituitary gland and can induce insulin secretion under high glucose conditions. Insulin secretion is regulated by various factors including glucagon-like peptide (GLP)-1, secreted from intestinal L-cells. GLP-1 is also expressed and secreted within islets and termed as "intra-islet GLP-1". The study aims to elucidate the impact of Oxt on insulin secretion in relation to intra-islet GLP-1.
methodsWe measured changes in blood glucose and insulin levels following Oxt administration in wild-type (WT) and Oxt receptor knockout (OxtR KO) mice. Additionally, we assessed insulin secretion from islets isolated from WT and OxtR KO mice under conditions with and without Oxt. Histological analysis of OxtR expression in islets was performed. The effects of Oxt on factors influencing insulin secretion, such as glucagon, GLP-1 secretion from WT islets and K
resultsOxt injection induced a temporal rise in blood glucose levels in both WT and OxtR-KO mice at 15-min post-injection. In WT mice, blood glucose level returned to control levels by 30min and were significantly lower at 60-min. OxtR KO mice maintained elevated glucose levels at 30-min. WT mice showed a significant increase in insulin levels at 15-min, while OxtR KO mice did not. OxtR was expressed in both insulin and glucagon-positive cells with higher expression in glucagon-positive cells. WT islets showed an increase in intra-islet GLP-1 secretion upon Oxt application.
conclusionsThe study indicates that Oxt may enhance insulin secretion by promoting the secretion of intra-islet GLP-1.
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