ArticleJournal of cosmetic dermatology2025
Permeation of Nicotinamide Mononucleotide (NMN) in an Artificial Membrane as a Cosmetic Skin Permeability Test Model.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSkin aging progresses owing to intrinsic factors, including chronological alterations, and extrinsic factors, including ultraviolet radiation (UV), smoking, and air pollution. One of the mechanisms of aging is a decrease in NAD
aimThis Study Aimed to Evaluate the Permeability, Functionality, and Stability of NMN in Cosmetics.
methodsThe permeation of NMN contained in a yeast-fermented filtrate (YFF) was evaluated in vitro using artificial skin membranes (Strat-M). Localization of NMN in the membrane was detected by MALDI-imaging mass spectrometry (MALDI-IMS) analysis. Collagen production in dermal fibroblasts was determined using Collagen Type I pro (ELISA). The analysis of the NMN degradation reaction and the determination of the half-life of NMN in the YFF were performed using high-performance liquid chromatography.
resultsNMN Permeated and Was Detected Only in the Papillary Dermis Region of the Membrane by MALDI-IMS. Furthermore, Collagen Type 1 Production Was Increased in Human Fibroblasts When Treated With NMN. On the Other Hand, the NMN Degradation Reaction Was a First-Order Reaction, and the Half-Life of NMN in the YFF Was Approximately 7 months at 20°C. These Results Suggest That NMN Was Relatively Stable in the YFF and Did Not Reach the Subcutaneous Tissue, and That NMN Increased Collagen Production by Fibroblasts in the Papillary Dermis.
conclusionsNMN in the YFF permeated artificial skin membranes, and NMN contained in YFF enhanced collagen Type 1 production in fibroblasts. Therefore, the YFF, containing NMN, may be a potential cosmetic ingredient.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.