Evidence map›Paper›PMID 40317496›Full record

GuidelineJournal of the European Academy of Dermatology and Venereology : JEADV2025

European Guideline (EuroGuiDerm) on atopic eczema: Living update.

A Wollenberg, M Kinberger, B Arents, N Aszodi, S Barbarot, T Bieber, H A Brough, P Calzavara-Pinton, S Christen-Zaech, M Deleuran and 22 more

Abstract readPractice Guideline
In one paragraph

Guideline in Journal of the European Academy of Dermatology and Venereology : JEADV, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. European Guideline (EuroGuiDerm) on atopic eczema: Living update.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025
    Guideline
  2. Article
  3. Article
  4. Article
  5. Article
  6. Pharmacological assessment of drugs retained in the 1Naunyn-Schmiedeberg's archives of pharmacology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Dupilumab versus tralokinumab in atopic dermatitis: A propensity score adjusted comparison from BioDay.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
    Article
  13. Article
  14. Review
  15. Biomarkers in atopic dermatitis: Current evidence and unmet needs.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
    Article
  16. Article
  17. Article
  18. Severity bands for atopic dermatitis measures: Analysis from adult dupilumab randomized clinical trials.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
    Article
  19. Atopic dermatitis.Nature reviews. Disease primers · 2026
    Review
  20. Multi-Kingdom Synergy ofLife (Basel, Switzerland) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

A WollenbergDepartment of Dermatology and Allergology, University Hospital Augsburg, Augsburg, Germany.ORCID https://orcid.org/0000-0003-0177-8722
M KinbergerDivision of Evidence-Based Medicine (dEBM), Department of Dermatology, Venereology and Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0002-7673-9974
B ArentsEuropean Federation of Allergy and Airways Diseases Patients' Associations (EFA), Brussels, Belgium.
N AszodiDepartment of Dermatology and Allergy, Ludwig Maximilian University Munich, Munich, Germany.
S BarbarotDepartment of Dermatology, Nantes Université, CHU Nantes, UMR 1280 PhAN, INRAE, Nantes, France.ORCID https://orcid.org/0000-0002-6629-9100
T BieberChristine Kühne-Center for Allergy Research and Education, Medicine Campus, Davos, Switzerland.
H A BroughChildren's Allergy Service, Evelina London Children's Hospital, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
P Calzavara-PintonDermatology Department, University of Brescia, Brescia, Italy.
S Christen-ZaechUniversity Hospital Lausanne, Lausanne, Switzerland.
M DeleuranDepartment of Dermatology, Aarhus University Hospital and Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0003-0593-9925
M DittmannDivision of Evidence-Based Medicine (dEBM), Department of Dermatology, Venereology and Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.
N FosseDepartment of Dermatology, University Hospital Basel, Basel, Switzerland.
K GáspárDepartment of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
L A A GerbensDepartment of Dermatology, Amsterdam UMC, Academic Medical Center, Amsterdam Public Health & Infection and Immunity, University of Amsterdam, Amsterdam, The Netherlands.
U GielerDepartment of Dermatology, University of Giessen, Giessen, Germany.
G GirolomoniDermatology and Venereology Section, Department of Medicine, University of Verona, Verona, Italy.ORCID https://orcid.org/0000-0001-8548-0493
S GregoriouFaculty of Medicine, National and Kapodistrian University of Athens, Athens, Greece.ORCID https://orcid.org/0000-0002-7585-1032
S HollandEczema Outreach Support (UK), Linlithgow, UK.
C G MortzDepartment of Dermatology and Allergy Centre, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
A NastDivision of Evidence-Based Medicine (dEBM), Department of Dermatology, Venereology and Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0003-3504-2203
U NygaardDepartment of Dermato-Venerology, Aarhus University Hospital, Aarhus, Denmark.
E M RehbinderDermatology Department, Oslo University Hospital, Oslo, Norway.
J RingDepartment of Dermatology and Allergology Biederstein, Technical University Munich, Munich, Germany.ORCID https://orcid.org/0000-0001-8236-3152
M RossiDermatology Department, University of Brescia, Brescia, Italy.
E Serra-BaldrichDermatology, Hospital of Sant Pau, Barcelona, Spain.
D SimonDepartment of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Z Z SzalaiPediatric Dermatology Unit, Heim Pál National Children's Institute Budapest, Budapest, Hungary.
J C SzepietowskiDepartment of Dermato-Venereology, 4th Military Hospital, Wroclaw, Poland.ORCID https://orcid.org/0000-0003-0766-6342
A TorreloHospital Infantil Niño Jesús, Madrid, Spain.
T WerfelDepartment of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
R N WernerDivision of Evidence-Based Medicine (dEBM), Department of Dermatology, Venereology and Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0003-3209-1392
C FlohrSt John's Institute of Dermatology, King's College London, London, UK.ORCID https://orcid.org/0000-0003-4884-6286

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The evidence- and consensus-based living guideline on atopic eczema was developed in accordance with the EuroGuiDerm Guideline and Consensus Statement Development Manual. The original EuroGuiDerm Guideline on atopic eczema was published in June 2022. Since then, the part of the guideline dealing with systemic therapy has been updated twice. This paper summarizes the results of the second update. Twenty-eight experts (including clinicians and patient representatives) from 12 European countries participated. The updated guideline provides guidance on which patients should be treated with systemic therapies, as well as recommendations and detailed information on each systemic drug. The systemic treatment options discussed in the guideline comprise conventional immunosuppressive drugs (azathioprine, ciclosporin, glucocorticosteroids, methotrexate and mycophenolate mofetil), biologics (dupilumab, lebrikizumab, nemolizumab and tralokinumab) and Janus kinase (JAK) inhibitors (abrocitinib, baricitinib and upadacitinib). Additionally, the updated guidelines address considerations for paediatric, adolescent, pregnant and breastfeeding patients. For all other aspects, please refer to the 2022 version.

Indexed as

Dermatitis, AtopicImmunosuppressive AgentsAdolescentBiological ProductsBreast FeedingChildEuropeFemaleHumansJanus Kinase InhibitorsPregnancyBiological ProductsImmunosuppressive AgentsJanus Kinase Inhibitors

Identifiers

PMID40317496
PMCPMC12376260

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.