Evidence map›Paper›PMID 40317421›Full record

ArticleBiogerontology2025

Synbiotic pineapple beverage increases life span in Caenorhabditis elegans, ameliorates cognitive impairment, and restores gut microbiome diversity in D-galactose-induced aged C57BL/6 mice.

Neelam Anil Revankar, Siddaraju Anusha, Serva Peddha Muthukumar, Pradeep Singh Negi

Abstract read
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In one paragraph

Article in Biogerontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Neelam Anil RevankarDepartment of Fruit and Vegetable Technology, CSIR-Central Food Technological Research Institute, Mysuru, 570020, India.
Siddaraju AnushaDepartment of Fruit and Vegetable Technology, CSIR-Central Food Technological Research Institute, Mysuru, 570020, India.
Serva Peddha MuthukumarDepartment of Biochemistry, CSIR-Central Food Technological Research Institute, Mysuru, 570020, India.
Pradeep Singh NegiDepartment of Fruit and Vegetable Technology, CSIR-Central Food Technological Research Institute, Mysuru, 570020, India. psnegi@cftri.res.in.ORCID 0000-0002-0458-6294

Funding

Central Food Technological Research Institute, Council of Scientific and Industrial Research MLP284
6 · The paper itself

Abstract

The incidence of age-associated ailments has increased proportionately with the expansion of the aging demographic. This study aimed to evaluate the anti-aging potential of synbiotic pineapple beverage formulated with 100% pineapple juice, 1% inulin, and Lacticaseibacillus rhamnosus ATCC 53103 (10 log CFU) in Caenorhabditis elegans and D-galactose age-induced mice. The synbiotic juice-treated nematodes exhibited a 24.52% increase in their lifespan, accompanied by lower levels of reactive oxygen species and improved structural functions. In vivo studies demonstrated that synbiotic treatment positively influences age-induced mice's cerebellar function and spatial memory. Additionally, the synbiotic beverage containing 8-10 log CFU of Lacticaseibacillus rhamnosus showed a protective effect against hippocampal neuron damage. The control group displayed a higher Firmicutes/Bacteroides (F/B) ratio, whereas the significantly lower F/B ratio in the diseased groups indicated a reversal of microbial imbalance caused by D-galactose exposure. Furthermore, the consumption of synbiotic beverage mitigated telomere shortening in aged mice. The results highlight the anti-aging effects of a pineapple beverage formulated with Lacticaseibacillus rhamnosus and inulin as a synbiotic intervention. This study suggests that dietary interventions incorporating prebiotics and probiotics may serve as promising strategy for combating age-related disorders and promoting healthy aging.

Indexed as

AgingAnanasCognitive DysfunctionGastrointestinal MicrobiomeLongevitySynbioticsAnimalsBeveragesCaenorhabditis elegansGalactoseMaleMiceMice, Inbred C57BLGalactoseCaenorhabditis elegansD-galactose-induced aged miceInulinLacticaseibacillus rhamnosusPineappleSynbiotics

Identifiers

PMID40317421

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.