Evidence map›Paper›PMID 40317414›Full record

ArticleMolecular neurobiology2025

Carnosic Acid Attenuated the Motor Impairment by Bisphenol A is Related to the Regulation of Autophagy Through Parkin in In Vitro and In Vivo.

Chun-Huei Liao, Ya-Chen Shih, Hsi-Yun Huang, Jing-Wei Chen, Shao-I Hsu, Chiao-Ni Lai, Ru-Huei Fu, Chia-Wen Tsai

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Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chun-Huei Liao *Department of Nutrition, China Medical University, Taichung, Taiwan.
Ya-Chen ShihDepartment of Nutrition, China Medical University, Taichung, Taiwan.
Hsi-Yun HuangDepartment of Nutrition, China Medical University, Taichung, Taiwan.
Jing-Wei ChenDepartment of Nutrition, China Medical University, Taichung, Taiwan.
Shao-I HsuDepartment of Nutrition, China Medical University, Taichung, Taiwan.
Chiao-Ni LaiDepartment of Nutrition, China Medical University, Taichung, Taiwan.
Ru-Huei Fu *Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
Chia-Wen TsaiDepartment of Nutrition, China Medical University, Taichung, Taiwan. cwtsai@mail.cmu.edu.tw.

Funding

China Medical University, Taiwan CMU111-S-13Ministry of Science and Technology MOST 110-2320-B-039-050-MY3
6 · The paper itself

Abstract

Bisphenol A (BPA) is an endocrine-disrupting compound linked to impairments in motor function and the manifestation of anxiety-like behaviors. The present study investigated the effects of carnosic acid (CA) on BPA-induced motor deficits and explored the role of parkin in the autophagic mechanism. First, C57BL/6 J male mice were orally administered with CA (5 mg/kg and 20 mg/kg) or RE (80 mg/kg rosemary extract) to test the motor function and anxiety-like behaviors in BPA (50 μg/kg) treatment. The results showed that CA and RE ameliorate BPA-induced motor impairments and anxiety-like behaviors. Moreover, CA and RE attenuated BPA-induced phosphorylation of tau and α-synuclein while restoring the expression levels of autophagy-related proteins, including parkin, PINK1, PI3K, Atg7, Beclin1, and LC3B-II. Then, SH-SY5Y cells were treated with 20 nM BPA and 1 μM CA or 0.5 μg/mL RE for 18 h. The results showed that treatment of CA and RE with BPA activated the parkin pathway and reduced the levels of

Indexed as

AbietanesAutophagyBenzhydryl CompoundsMotor ActivityPhenolsUbiquitin-Protein Ligasesalpha-SynucleinAnimalsBisphenol A CompoundsCell Line, TumorHumansMaleMiceMice, Inbred C57BLPhosphorylationPlant ExtractsAbietanesalpha-SynucleinBenzhydryl Compoundsbisphenol ABisphenol A Compoundsparkin proteinPhenolsPlant Extractssalvintau ProteinsUbiquitin-Protein LigasesAutophagyBisphenol AC57BL/6 miceCarnosic acidMotor impairmentSH-SY5Y cells

Identifiers

PMID40317414

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.