Trial reportActa neurologica Belgica2025
Analysis of MEP parameters in patients with post stroke spasticity in relation with rTMS therapy.
Trial report in Acta neurologica Belgica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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Who cites it
1 citing paper in PubMed.
- Advances in the diagnosis and management of post-stroke limb spasticity: a narrative review.Frontiers in neurologyReview
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgorundSpasticity is a common complication of stroke limiting patient's daily activities. Transcranial magnetic stimulation is a painless and non-invasive method that can potentially reduce post-stroke spasticity (PSS). Motor evoked potentials (MEP) parameters have been shown to be related with prognosis of stroke patients. In this study we analysed the changes in MEP parameters after 3 sessions of low Hz rTMS therapy among PSS patients.
methodsPatients with upper limb spasticity after stroke of 3 months duration were randomised into active and sham groups. In the active group three sessions of 1000 pulses, 1 Hz rTMS at an intensity of 90% of resting motor threshold were applied to the primary motor area of the contra-lesional hemisphere over three consecutive days. Sham rTMS intensity was 0% with coil placed over scalp for same duration. MEP was measured pre and post therapy in each group.
results106 patients were screened of which 50 patients were selected. 25 patients were allotted to active group and 25 to sham group. Mean amplitude of MEP on stimulation of normal side was 1.98±1.70 mV before versus 1.53±1.16 mV after therapy showing significant reduction p=0.001 (95% CI-.135 - -.630). Similarly, there was significant increase in latency after therapy [22.92±2.25 ms vs 24.26±2.62 ms, p=0.001 (95% CI-2.0 - -.96)]. There was no significant change in amplitude (1.05±.69 mV vs 1.17±1.01 mV) or latency (23.66±2.45 ms vs 24.05±2.58 ms) after therapy in sham group.
conclusionMEP parameters revealed even three sessions of therapy can be helpful in supressing normal hemisphere. We found reduction in amplitude and increase in latency of MEP after low Hz rTMS therapy in contra-lesional hemisphere suggesting its suppression after therapy.
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