Evidence map›Paper›PMID 40317401›Full record

ReviewCurrent neurology and neuroscience reports2025

Thrombectomy Selection in the Large Core Era: Implications for Regional Transfers.

Luigi Cirillo, Mohamad Abdalkader, Piers Klein, Vivek S Yedavalli, James E Siegler, Matthew Kang, Liqi Shu, Fawaz Al Mufti, Shadi Yaghi, Anna Ranta and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current neurology and neuroscience reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Luigi CirilloNeuroradiology Unit, IRCCS Institute of Neurological Sciences of Bologna, Bologna, Italy.
Mohamad AbdalkaderRadiology, Boston Medical Center, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, 02118, USA.
Piers KleinRadiology, Boston Medical Center, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, 02118, USA.
Vivek S YedavalliRadiology, Johns Hopkins University School of Medicine, Baltimore, USA.
James E SieglerNeurology, University of Chicago, Chicago, USA.
Matthew KangRadiology, Boston Medical Center, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, 02118, USA.
Liqi ShuNeurology, Rhode Island Hospital, Providence, USA.
Fawaz Al MuftiNeurology, Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY, USA.
Shadi YaghiNeurology, Rhode Island Hospital, Providence, USA.
Anna RantaNeurology, Wellington Hospital; Medicine, University of Otago, Wellington, New Zealand.
Thanh N NguyenRadiology, Boston Medical Center, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, 02118, USA. thanh.nguyen@bmc.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThis review aims to evaluate recent advances in large core stroke management with a focus on diagnostic imaging protocols to select patients for endovascular therapy. RECENT

findingsRecent randomized controlled trials have shown that thrombectomy can lead to favorable outcomes in patients with large infarcts, contradicting previous assumptions that thrombectomy was not indicated in such patients due to higher risks and very low benefits. Although mechanical thrombectomy remains the gold standard of medical treatment for large vessel occlusions with demonstrated salvageable brain tissue, analysis of the results of recent randomized trials in patients with large ischemic stroke should help us expand patient selection, optimize timing, and explore different management modalities to improve the outcomes of therapy in these patients.

Indexed as

Ischemic StrokePatient SelectionPatient TransferStrokeThrombectomyEndovascular ProceduresHumansRandomized Controlled Trials as TopicLarge coreStrokeTandem occlusionThrombectomy

Identifiers

PMID40317401

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.