Observational studyWorld journal of urology2025
Influence of tumour location on the survival outcomes of upper tract urothelial carcinoma treated with radical nephroureterectomy.
Observational study in World journal of urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02281188 (Registry for Treatment of Upper Urinary Tract Tumours; A Multi-Center, International Registry to Evaluate the Treatment of Upper Tract Urothelial Cancer), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Registry for Treatment of Upper Urinary Tract Tumours; A Multi-Center, International Registry to Evaluate the Treatment of Upper Tract Urothelial Cancer: Incidence, Indications, Treatment Types and Outcomes.
Who cites it
2 citing papers in PubMed.
- Stage-Specific Prognostic Impact of Tumor Location in Upper Tract Urothelial Carcinoma: A Propensity Score-Matched Analysis.Annals of surgical oncology · 2026Observational
- Development of a predictive risk score for 1-year intravesical recurrence after radical nephroureterectomy for upper tract urothelial carcinoma.Central European journal of urology · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the impact of tumour location on the survival outcomes of patients with upper tract urothelial carcinoma (UTUC) after radical nephroureterectomy (RNU).
methodPatients with ureteral urothelial carcinoma (UUC) or renal pelvic urothelial carcinoma (RPUC) of the Clinical Research Office of the Endourology Society (CROES)-UTUC registry were analyzed. Study outcomes included overall survival (OS), cancer-specific survival (CSS), intravesical recurrence-free survival (IRFS), and progression-free survival (PFS), which were compared using Kaplan-Meier method with log-rank test. Propensity score matching (PSM) was performed to balance the differences in tumour features between the two groups.
resultThe UUC and RPUC groups consisted of 309 (41.9%) and 429 (58.1%) patients, respectively. RPUC group had larger tumour size (77.9% ≥ 2 cm vs 67.0% in UUC, p < 0.01), and more T3/T4 tumours (36.4% vs. 22. 0%, p < 0.01). The UUC group exhibited worse PFS compared to the RPUC group ( p = 0.029 for the initial analysis and p = 0.013 after PSM). However, there were no significant differences in OS (p = 0.088 before PSM and p = 0.255 after PSM), CSS (p = 0.106 before PSM and p = 0.101 after PSM), or IRFS (p = 0.112 before PSM and p = 0.28 after PSM) between the two groups.
conclusionPatients with ureteral urothelial carcinoma exhibited worse PFS compared to those with renal pelvic urothelial carcinoma. However, no significant differences were observed in OS, CSS, or IRFS between the two tumour locations. UTUC patients should be counselled about their individualized prognosis accordingly. REGISTRATION: NCT02281188.
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