ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2025
Endplate fractures with subtle structural damage in impact loaded flexed ovine lumbar segments: a potential initiator of disc degeneration.
Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- A Comparison of Five Animal Models for Acute Intervertebral Disc Herniation Research.JOR spine · 2025Article
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Authors and funding
4 authors.
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Abstract
purposeTo (a) investigate patterns of structural damage in flexed, healthy ovine lumbar motion segments subjected to controlled impact loading approximating a low energy traumatic fall; and (b) determine the relative risk of herniation, endplate failure and other subtle modes of structural disruption as potential mechanical initiators of disc degeneration.
methodsTwenty-three healthy ovine lumbar motion segments were flexed 7° and then impact loaded by dropping a weight of 4.3 kg from a height of 0.8 m. Each sample was macroscopically assessed externally for herniations and then sagittally bisected to assess internal structural damage.
resultsFifteen segments suffered endplate failure, 7 herniated, and 1 suffered both an endplate fracture and herniation. Thirteen segments had a major fracture of the superior endplate and 8 of these also contained subtle damage in the anterior annulus and/or inferior vertebra. Overall, both herniated and endplate fractured samples indicated an oblique mode of failure tending from posterior-superior to anterior-inferior. Other forms of subtle tissue damage were observed across all visible regions of the disc, these coexisting with the major modes of failure.
conclusionFlexed ovine lumbar motion segments subjected to impact loading approximating a low energy traumatic fall, are more likely to fail via endplate fracture accompanied by more subtle structural damage in the disc and/or adjacent vertebra. Failure by disc herniation was less common. The subtle, co-occurring, multi-component failure modes add to our recognition of the complexity of these injuries, and the potential role they might play in the initiation and development of the degenerative cascade in the intervertebral disc.
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