Evidence map›Paper›PMID 40317277›Full record

ReviewThe Journal of investigative dermatology2025

CD1a and Lipids as Mediators of T Cell Activation in the Skin.

Lauren M Fahmy, Oluwaseyi O Adeuyan, Annemieke de Jong

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of investigative dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lauren M FahmyDepartment of Dermatology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York, USA.
Oluwaseyi O AdeuyanDepartment of Dermatology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York, USA.
Annemieke de JongDepartment of Dermatology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York, USA. Electronic address: ad2952@cumc.columbia.edu.

Funding

Role of secreted phospholipase A2 in the activation of human CD1-restricted T cellsR01AR074037 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DE JONG, ANNEMIEKE · 2019 to 2024
$1.7M
Activation of human CD1a-restricted T cells by bacterial and mitochondrial lipidsR21AI185955 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Annemieke de Jong · 2025 to 2026
$420k
NIAID NIH HHS R21 AI185955NIAMS NIH HHS R01 AR074037
6 · The paper itself

Abstract

Despite increasing insights in cytokine pathways involved in T cell-mediated inflammatory skin diseases, the upstream T cell triggering events through antigen-presenting molecules and antigens often remain incompletely understood. Recent studies have proposed an immunopathogenic role for T cells that are activated through CD1a, a lipid antigen-presenting molecule abundantly expressed on antigen-presenting cells in human skin. These CD1a-restricted T cells are thought to play a role in psoriasis, atopic dermatitis, and allergic contact dermatitis. In this review, we discuss modes of T cell activation by CD1a proteins and lipid antigens and bacteria as well as recent insights in local and systemic functions of CD1a-restricted T cells in inflammatory skin disease.

Indexed as

Antigens, CD1LipidsLymphocyte ActivationSkinT-LymphocytesAnimalsAutoimmunityHumansSkin DiseasesAntigens, CD1CD1a antigenLipidsCD1aInflammatory skin diseasesLangerhans cellsLipid antigensT cells

Identifiers

PMID40317277
PMCPMC12320715

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.