Evidence map›Paper›PMID 40317212›Full record

ReviewNeuro-oncology2025

Response Assessment in Neuro-Oncology (RANO) 2009-2025: Broad scope and implementation-A progress report.

Martin J van den Bent, Michael A Vogelbaum, Tim Cloughesy, Norbert Galldiks, Nathalie L Albert, Joerg-Christian Tonn, Edward Avila, Jason Fangusaro, David Mirsky, Arjun Sahgal and 25 more

Abstract readReview
In one paragraph

Review in Neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Accelerating discovery: Transformative clinical trial models in neuro-oncology.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Review
  5. Review
  6. Imaging in Neuro-oncology.Seminars in neurology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Martin J van den BentThe Brain Tumor Center at Erasmus MC Cancer Institute, Rotterdam, the Netherlands.ORCID 0000-0001-5710-5127
Michael A VogelbaumDepartment of NeuroOncology, Moffitt Cancer Center, Tampa, Florida, USA.
Tim CloughesyDepartment of Neurology, UCLA, California, USA.ORCID 0000-0002-8656-7483
Norbert GalldiksCenter for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Germany.ORCID 0000-0002-2485-1796
Nathalie L AlbertDepartment of Nuclear Medicine, LMU University Hospital of Munich, Munich, Germany.ORCID 0000-0003-0953-7624
Joerg-Christian TonnGerman Cancer Consortium (DKTK), Partner site Munich, Germany.ORCID 0009-0004-1756-423X
Edward AvilaDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, USA.ORCID 0000-0001-8489-2090
Jason FangusaroChildren's Healthcare of Atlanta, Emory University, and the Aflac Cancer Center, Atlanta, Georgia, USA.ORCID 0000-0003-3099-5259
David MirskyDepartment of Radiology, Pediatric Section, University of Colorado School of Medicine, Children's Hospital Colorado, Colorado, USA.ORCID 0000-0003-2162-515X
Arjun SahgalSunnybrook Odette Cancer Center, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-7991-8970
Ricardo SoffiettiDivision of Neuro-Oncology, Department of Neuroscience "Rita Levi Montalcini," University of Turin, Turin, Italy.ORCID 0000-0002-9204-7038
Philipp KarschniaDepartment of Neurosurgery, University Hospital Erlangen, Friedrich-Alexander University, Erlangen, Germany.ORCID 0000-0002-1254-5310
Minesh MehtaMiami Cancer Institute at Baptist Health of South Florida & Florida International University Department of Radiation Oncology, Miami, Florida, USA.ORCID 0000-0002-4812-5713
Michelle M KimDepartment of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0001-7566-6411
Florien BoeleLeeds Institute of Health Sciences, Faculty of Medicine and Health, University of Leeds, Leeds, UK.ORCID 0000-0003-0409-7949
Jason T HuseDepartments of Pathology and Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0003-4514-0640
Lakshmi NayakCenter for Neuro-Oncology, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-2725-8717
Mary Jane Lim-FatDivision of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-4317-5770
Emilie le RhunDepartment of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland.ORCID 0000-0002-9408-3278
Annick DesjardinsThe Preston Robert Tisch Brain Tumor Center at Duke, Department of Neurosurgery, Duke University, Durham, North Carolina, USA.ORCID 0000-0003-3869-8283
Eudocia Q LeeCenter for Neuro-Oncology, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-3355-5179
Ugonma ChukwuekeCenter for Neuro-Oncology, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-0598-9535
Johan A F KoekkoekDepartment of Neurology, Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0002-3648-9616
Tito MendozaOffice of Patient-Centered Outcomes Research, Center for Cancer Research, National Cancer Institute, National Institute of Health, Bethesda, Maryland, USA.ORCID 0000-0001-8122-5233
Ashlee R LoughanDepartment of Neurology, Division of Neuro-Oncology, Virginia Commonwealth University, Richmond, Virginia, USA.ORCID 0000-0003-1231-2469
Joshua A BudhuDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, USA.ORCID 0000-0002-8923-9784
Spyridon BakasIndiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, Indiana, USA.ORCID 0000-0001-8734-6482
Raymond Y HuangDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0001-7661-797X
Javier E Villanueva-MeyerNeurological Surgery at University of California, San Francisco, California, USA.ORCID 0000-0002-5910-0757
Jose Pablo LeoneDepartment of Medical Oncology, Brigham and Women's Hospital Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
Hideho OkadaParker Institute for Cancer Immunotherapy, San Francisco, CA, USA.ORCID 0000-0003-0076-9920
David A ReardonCenter for Neuro-Oncology, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0001-6674-0157
Wenya L BiDepartment of Neurosurgery Department of Neurosurgery, Mass General Brigham, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-4635-0247
Patrick Y WenCenter for Neuro-Oncology, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-0774-7700
Susan M ChangDivision of NeuroOncology, Department of Neurological Surgery, University of California San Francisco (UCSF), San Francisco, California, USA.ORCID 0000-0003-3521-364X

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI FRANCESCA M GANY · 1985 to 2026
$347.4M
Preclinical development of breakthrough immunotherapy for brain tumorsR35NS105068 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI OKADA, HIDEHO · 2018 to 2025
$6.0M
NCI NIH HHS P30 CA008748NINDS NIH HHS R35 NS105068
6 · The paper itself

Abstract

Since its first activities in 2008 and 2009, the Response Assessment in NeuroOncology (RANO) group has given guidance on response assessment, trial design, and trial procedures to improve and standardize the way clinical trials in neurooncological studies are performed. To achieve its objectives, a variety of working groups have been initiated that cover many aspects of clinical trial design and outcome assessment in patients with tumors affecting the Central Nervous System. The RANO working groups are built on expertise without a formal structure, which makes rapid responses to new developments possible. RANO is aiming at evidence-based guidelines and recommendations, but in the absence of evidence will provide consensus-based guidance achieved by inviting recognized international experts. In its 15 years of existence, more than 60 RANO papers have been published mostly in high-ranking journals, and its recommendations have been accepted by regulators and industry as guiding principles. RANO organizes two meetings per year, one in conjunction with the annual American Society for Clinical Oncology (ASCO) meeting, and one during the annual Society for Neuro-Oncology meeting. These meetings are open, as are the working groups of RANO. New initiatives are welcomed.

Indexed as

Brain NeoplasmsCentral Nervous System NeoplasmsClinical Trials as TopicMedical OncologyOutcome Assessment, Health CareHumansbrain metastasesoutcome criteriaprimary brain tumorsRANO

Identifiers

PMID40317212
PMCPMC12526114

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.