Evidence map›Paper›PMID 40317067›Full record

ArticleVeterinary research2025

SIRT2 inhibition enhances mitochondrial apoptosis in Brucella-infected bovine placental trophoblast cells.

Mengyu Zhang, Lin Qi, Junmei Li, NingQiu Yuan, Yunyi Zhai, Mingyue Hao, Dong Zhou, Wei Liu, Yaping Jin, Aihua Wang

Abstract read
In one paragraph

Article in Veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mengyu ZhangCollege of Veterinary Medicine, Northwest A&F University, Yangling District, Xianyang, 712100, China.ORCID http://orcid.org/0009-0007-4432-8437
Lin QiCollege of Veterinary Medicine, Northwest A&F University, Yangling District, Xianyang, 712100, China.
Junmei LiCollege of Veterinary Medicine, Northwest A&F University, Yangling District, Xianyang, 712100, China.
NingQiu YuanCollege of Veterinary Medicine, Northwest A&F University, Yangling District, Xianyang, 712100, China.
Yunyi ZhaiCollege of Veterinary Medicine, Northwest A&F University, Yangling District, Xianyang, 712100, China.
Mingyue HaoCollege of Veterinary Medicine, Northwest A&F University, Yangling District, Xianyang, 712100, China.
Dong ZhouCollege of Veterinary Medicine, Northwest A&F University, Yangling District, Xianyang, 712100, China.
Wei LiuCollege of Veterinary Medicine, Northwest A&F University, Yangling District, Xianyang, 712100, China.
Yaping JinCollege of Veterinary Medicine, Northwest A&F University, Yangling District, Xianyang, 712100, China.
Aihua WangCollege of Veterinary Medicine, Northwest A&F University, Yangling District, Xianyang, 712100, China. wangaihua@nwafu.edu.cn.

Funding

National Natural Science Foundation of China 32373016
6 · The paper itself

Abstract

Brucella is a successful pathogen that employs a plethora of immune evasion mechanisms. This contributes to pathogenesis and persistence and limits the efficacy of available treatments. An increasing understanding of host‒pathogen interactions suggests that integrating host-directed strategies with existing anti-Brucella treatments could lead to more effective bacterial clearance and a reduction in drug-resistant strains. SIRT2 is a nicotinamide adenine dinucleotide (NAD

Indexed as

ApoptosisBrucella abortusBrucellosis, BovineMitochondriaSirtuin 2TrophoblastsAnimalsCattleFemalePlacentaPregnancySirtuin 2bovine placental trophoblast cellsBrucellamitochondrial apoptosisSIRT2

Identifiers

PMID40317067
PMCPMC12049057

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.