Evidence map›Paper›PMID 40317062›Full record

ArticleJournal of medical case reports2025

Regenerative endodontic procedure using Emdogain: a case series.

Karime Tavares Lima da Silva, Meire Coelho Ferreira, Renata Grazziotin-Soares, Letícia Gomes Dourado, Claudia de Castro Rizzi Maia, Gisele Rodrigues da Silva, Ceci Nunes Carvalho

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Narrative Review of Endodontic Biomaterials.Biomimetics (Basel, Switzerland) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Karime Tavares Lima da SilvaCEUMA University, Rua Josué Montello n° 1, Renascença II, São Luís, MA, 65075120, Brazil.
Meire Coelho FerreiraCEUMA University, Rua Josué Montello n° 1, Renascença II, São Luís, MA, 65075120, Brazil.
Renata Grazziotin-SoaresDepartment of Oral Biological & Medical Sciences, Faculty of Dentistry, The University of British Columbia (UBC), Vancouver, BC, Canada.
Letícia Gomes DouradoCEUMA University, Rua Josué Montello n° 1, Renascença II, São Luís, MA, 65075120, Brazil.
Claudia de Castro Rizzi MaiaCEUMA University, Rua Josué Montello n° 1, Renascença II, São Luís, MA, 65075120, Brazil.
Gisele Rodrigues da SilvaDepartment of Operative Dentistry, Federal University of Uberlândia (UFU), Uberlândia, MG, Brazil.
Ceci Nunes CarvalhoCEUMA University, Rua Josué Montello n° 1, Renascença II, São Luís, MA, 65075120, Brazil. ceci.carvalho@ceuma.br.ORCID http://orcid.org/0000-0002-1706-4081

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 436087/2018-9Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão 03015/2018
6 · The paper itself

Abstract

backgroundEmdogain (Straumann CASES PRESENTATION: This report is a retrospective description of clinical findings from three regenerative treatments conducted under an identical protocol in two appointments using Emdogain as a scaffold. The three young Brazilian patients, aged 8, 8, and 12 years old (one female and two male), are from São Luís city, state of Maranhão. All three patients identify as Pardo ethnicity with brown skin color, come from low-income backgrounds, and had necrotic immature permanent teeth. Quantitative assessments of crown shades of treated teeth were determined with VITA Easyshade® Advance 4.0 spectrophotometer (VITA Zahnfabrik, Bad Sackingen, Germany) at baseline to 24-month follow-up. Self-reported pain was measured using the visual analogue scale (VAS) at the time of treatment (shortly after induction of bleeding into the canal) and at 7 day following the procedure. At 12 months, radiographic lesions were resolved. At 24 months there were apical closures, and the three teeth remained in function without symptomatology or signs of failure. All cases had the root length increased and the dentin wall thickened. One case presented radiographic images suggestive of scattered calcified zones in the root canal lumen.

conclusionEmdogain may be beneficial as a scaffold in regenerative endodontic procedures. The following outcomes were noted at 24-month follow-up: continuity of root formation, thickening of the root dentin walls, and closure of the root apex.

Indexed as

Dental Enamel ProteinsDental PulpDental Pulp NecrosisRegenerative EndodonticsChildFemaleHumansMaleRetrospective StudiesTissue ScaffoldsTreatment OutcomeDental Enamel Proteinsenamel matrix proteinsDental pulp necrosisEnamel matrix derivativeOdontogenesisRegenerative endodontics

Identifiers

PMID40317062
PMCPMC12046937

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.