Evidence map›Paper›PMID 40317039›Full record

ArticleCritical care (London, England)2025

SIGH

Antonio Messina, Lorenzo Calabrò, Francesco Benedetto, Aurora Villa, Guia Margherita Matronola, Andrea Brunati, Jean-Louis Teboul, Xavier Monnet, Maurizio Cecconi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Antonio MessinaIRCCS Humanitas Research Hospital, Via Manzoni 56, 20089, Rozzano, Milan, Italy. antonio.messina@humanitas.it.
Lorenzo CalabròDepartment of Intensive Care, Hôpital Universitaire (HUB), Brussels, Belgium.
Francesco BenedettoIRCCS Humanitas Research Hospital, Via Manzoni 56, 20089, Rozzano, Milan, Italy.
Aurora VillaDepartment of Anesthesia and Intensive Care, University Bicocca, Milan, Italy.
Guia Margherita MatronolaHumanitas University, Pieve Emanuele, Milan, Italy.
Andrea BrunatiHumanitas University, Pieve Emanuele, Milan, Italy.
Jean-Louis TeboulFaculté de Médecine Paris-Saclay, Université Paris-Saclay, Le Kremlin-Bicêtre, Paris, France.
Xavier MonnetAP-HP, Service de Médecine Intensive-Réanimation, Hôpital de Bicêtre, DMU CORREVE, Inserm UMR S_999, FHU SEPSIS, Groupe de Recherche Clinique CARMAS, Université Paris-Saclay, Le Kremlin-Bicêtre, Paris, France.
Maurizio CecconiIRCCS Humanitas Research Hospital, Via Manzoni 56, 20089, Rozzano, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAssessing fluid responsiveness is problematic for critically ill patients with spontaneous breathing activity, such as during Pressure Support Ventilation (PSV), since spontaneous breathing activity physiologically affects heart-lung interplay. We compared the reliability of two hemodynamic tests in predicting fluid responsiveness in this clinical setting: SIGH

methodsProspective study conducted in a general intensive care unit (ICU) and enrolling patients in PSV showing different inspiratory effort [assessed by airway occlusion pressure (P0.1)] and requiring volume expansion (VE). Hemodynamic variables were recorded by means of the MOSTCARE

resultsSixty ICU patients were enrolled, and 56 patients analysed. The AUC of PP changes after SIGH

conclusionsIn a selected ICU population undergoing PSV, SGH

Indexed as

Fluid TherapyPositive-Pressure RespirationAgedCardiac OutputCritical IllnessFemaleHemodynamicsHumansIntensive Care UnitsMaleMiddle AgedProspective StudiesReproducibility of ResultsROC CurveFluid responsivenessFluid therapyFunctional hemodynamic assessmentHemodynamic monitoringPressure support ventilationSigh manoeuvre

Identifiers

PMID40317039
PMCPMC12046741

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.