ArticleBMC oral health2025
Use of serum albumin levels and salivary biomarkers in assessing periodontal disease: a community hospital perspective.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Association between Albumin-to-Globulin Ratio and Periodontitis: A Cross-Sectional and Mendelian Randomisation Analysis.Oral health & preventive dentistry · 2026Article
- Relationships Between Salivary Biomarkers and Oral Function in Elderly People Using a Saliva Testing Device.Dentistry journal · 2026Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
backgroundPeriodontal status can be reflected in serum and oral biomarkers. Salivary biomarkers are novel screening tools for individuals with dentophobia or disabilities. This study aimed to explore the differences in SiLL-Ha results and serum albumin levels between clinical attachment loss (CAL) ≥ 5 mm (Group A) and CAL < 5 mm (Group B) as well as the influence of sex on these differences.
methodsThis study recruited healthy adults aged 35-80 years from a community hospital. Participants completed a demographic questionnaire. We collected the participants' medical history, including hypertension, diabetes mellitus (DM) and hyperlipidemia, from electronically stored medical records. Additionally, they underwent a collaborated saliva test, an oral examination including records of clinical attachment levels, and a blood test to measure albumin levels sequentially. Participants were divided into Group A and Group B based on a CAL cut-off point of 5 mm. Multivariable logistic regression was used to analyze associations between the SiLL-Ha results, serum albumin levels, periodontitis, and sex stratification.
resultsThe mean age of the 231 participants was 64.4 years, and 58.4% were women. Older age, low serum albumin levels, and high blood levels of SiLL-Ha were associated with periodontitis. Among the women, age and blood level of SiLL-Ha output were significantly associated with periodontitis. Among men, serum albumin level was significantly associated with periodontitis. Participants with DM were less likely to have periodontitis, particularly females.
conclusionsThe saliva test is a noninvasive tool applicable not only in dental clinics but also in community settings. It is beneficial for self-monitoring of oral health and promoting health awareness and behavior.
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