Evidence map›Paper›PMID 40316915›Full record

ArticleBMC plant biology2025

Integrated metabolomics and transcriptomics analysis comprehensively revealed the underlying metabolite mechanism difference between Male and Female Eucommia ulmoides Oliver.

Pei-Lu Wang, Jin-Ling You, Qian-Ming Hua, Hua-Qiang Li, Qi Shi, Wen-Long Li, Yun-Jie Sheng, Kao-Hua Liu, Bing-Qian He, Qiao-Yan Zhang and 2 more

Abstract read
In one paragraph

Article in BMC plant biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Pei-Lu Wang *School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District, Hangzhou, Zhejiang, P.R. China.
Jin-Ling You *School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District, Hangzhou, Zhejiang, P.R. China.
Qian-Ming Hua *Hangzhou TCM Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, P.R. China.
Hua-Qiang LiSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District, Hangzhou, Zhejiang, P.R. China.
Qi ShiSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District, Hangzhou, Zhejiang, P.R. China.
Wen-Long LiSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District, Hangzhou, Zhejiang, P.R. China.
Yun-Jie ShengSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District, Hangzhou, Zhejiang, P.R. China.
Kao-Hua LiuSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District, Hangzhou, Zhejiang, P.R. China.
Bing-Qian HeAcademy of Chinese Medical Science, Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District, Hangzhou, Zhejiang, 310053, P. R. China.
Qiao-Yan ZhangSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District, Hangzhou, Zhejiang, P.R. China. zqy1965@163.com.
Lu-Ping QinSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District, Hangzhou, Zhejiang, P.R. China. lpqin@zcmu.edu.cn.
Xiong-Yu MengSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, 548 Binwen Road, Binjiang District, Hangzhou, Zhejiang, P.R. China. mengxiongyu@zcmu.edu.cn.

Funding

2024 General Research Project of Zhejiang Provincial Department of Education Y202456199Zhejiang Chinese Medical University Research Foundation 2023JKZKTS24Zhejiang Province Traditional Chinese Medicine Science and Technology Project 2023ZF087Zhejiang Provincial Medicine and Health Science and Technology Plan Project 2022490995Zhejiang Provincial Natural Science Foundation of China LQ22H270004Zhejiang Provincial Natural Science Foundation of China LTGC24H270001
6 · The paper itself

Abstract

backgroundEucommia ulmoides Oliver is a dioecious plant with great economic value, but the underlying metabolite mechanism difference between male and female E. ulmoides remain poorly understood.

resultsIn this study, we integrated a dual-platform metabolomics approach with transcriptomics to systematically analyze differences in metabolite and gene expression in the cortex and leaves of male and female E. ulmoides. As a result, 1,452 metabolites (603 volatile, 849 non-volatile) were characterized, and 156 and 129 differentially accumulated metabolites were identified in FEC vs. MEC and FEF vs. MEF, respectively. The expression of key genes (PLA2G4, DOXs, LOX2S, and CEQORH) involved in alpha-linolenic acid metabolism was significantly altered in MEC. Similarly, the expression of key genes (CHS, FLS, DFR, and ANR) involved in flavonoid biosynthesis was significantly altered in MEF.

conclusionsOur findings shed light on the metabolite mechanism behind the metabolic differences between male and female E. ulmoides and contribute to the exploration of value utilization.

Indexed as

EucommiaceaeMetabolomeTranscriptomeGene Expression ProfilingGene Expression Regulation, PlantMetabolomicsPlant LeavesDioecious plantEucommia ulmoides OliverMetabolomicsTranscriptomics

Identifiers

PMID40316915
PMCPMC12048979

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