Evidence map›Paper›PMID 40316897›Full record

ArticleBMC genomics2025

Postnatal epigenetic differences in calves following transient fetal infection with bovine viral diarrhea virus.

Jessica N Kincade, Terry E Engle, Marcela Henao-Tamayo, Jordan M Eder, Erin M McDonald, Darcy M Deines, Brie M Wright, Dilyara Murtazina, Jeanette V Bishop, Thomas R Hansen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jessica N KincadeDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.ORCID http://orcid.org/0000-0003-3699-699X
Terry E EngleDepartment of Animal Sciences, Colorado State University, Fort Collins, CO, USA.ORCID http://orcid.org/0000-0003-1626-1830
Marcela Henao-TamayoDepartment of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA.ORCID http://orcid.org/0000-0002-4249-9650
Jordan M EderResearch Innovation Center, Fort Collins, CO, USA.ORCID http://orcid.org/0000-0002-7054-3057
Erin M McDonaldResearch Innovation Center, Fort Collins, CO, USA.ORCID http://orcid.org/0000-0002-6983-4594
Darcy M DeinesResearch Innovation Center, Fort Collins, CO, USA.
Brie M WrightResearch Innovation Center, Fort Collins, CO, USA.
Dilyara MurtazinaDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.ORCID http://orcid.org/0000-0001-6618-9254
Jeanette V BishopDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
Thomas R HansenDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA. thomas.hansen@colostate.edu.ORCID http://orcid.org/0000-0001-7244-8769
Hana Van CampenDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA. hana.van_campen@colostate.edu.ORCID http://orcid.org/0000-0003-3100-9174

Funding

National Institute of Food and Agriculture 2019-67015-29866National Institute of Food and Agriculture 2021-38420-34040National Institute of Food and Agriculture 2023-67011-40513
6 · The paper itself

Abstract

backgroundBovine viral diarrhea virus (BVDV) is the most detrimental pestivirus within the cattle industry. Infection with vertically transmissible BVDV prior to 125 days of gestation results in the generation of a persistently infected (PI) calf. These PI calves are unable to clear the virus in utero, due to an incomplete immune response. However, when infection with BVDV occurs after 150 days of gestation, the fetus clears the transient infection (TI) in utero and is born with antibodies specific to the infecting strain of BVDV. Variations in DNA methylation have been identified in white blood cells (WBC) from TI heifers at birth. It was hypothesized that epigenomic alterations persist into the postnatal period and contribute to previously undocumented pathologies. To study these possible effects, DNA was isolated from the WBCs of 5 TI heifers and 5 control heifers at 4 months of age and subjected to reduced representation bisulfite sequencing (RRBS).

resultsDifferential analysis of the methylome revealed a total of 3,047 differentially methylated CpG sites (DMSs), 1,349 of which were hypermethylated and the other 1,698 were hypomethylated. Genes containing differential methylation were associated with inflammation, reactive oxygen species (ROS) production, and metabolism. Complete blood count (CBC) data identified a higher lymphocyte percentage in TI heifers. When compared in the context of the CD45

conclusionDifferential methylation of WBC DNA persists to 4 months of age in TI heifers and is associated with dysregulation of inflammation, metabolism, and growth. Analysis of differential methylation in TI heifers contributes to the understanding of how fetal infection with BVDV induces postnatal detriments related to profit loss.

Indexed as

Bovine Virus Diarrhea-Mucosal DiseaseDiarrhea Viruses, Bovine ViralEpigenesis, GeneticAnimalsCattleCpG IslandsDNA MethylationFemaleLeukocytesPregnancyBVDVEpigeneticsFetal infectionMethylationTransient infection

Identifiers

PMID40316897
PMCPMC12049026

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.