Evidence map›Paper›PMID 40316818›Full record

ArticleScientific reports2025

GIMAP8 could serve as a potential prognostic factor for lung adenocarcinoma and is closely related to immunity.

Xinfeng Wei, Wei Wei, Hongmei Liu, Junxuan Yi, Mingwei Wang, Weiqiang Xu, Mingqi Zhao, Mengdie Zhao, Rong Wang, Shunzi Jin

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PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xinfeng WeiNHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, Jilin, China.
Wei WeiDepartment of Radiation Oncology, Senior Department of Oncology, The Fifth Medical Center of PLA General Hospital, Beijing, China.
Hongmei LiuNanguan Hospital of Bethune Second Hospital of Jilin University, Changchun, China.
Junxuan YiNHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, Jilin, China.
Mingwei WangNHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, Jilin, China.
Weiqiang XuNHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, Jilin, China.
Mingqi ZhaoNHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, Jilin, China.
Mengdie ZhaoNHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, Jilin, China.
Rong WangDepartment of Radiation Oncology, Zhongshan City People's Hospital, No. 2, Sunwen East Road, Zhongshan, Guangdong, China. wangrongfypl@126.com.
Shunzi JinNHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, Jilin, China. jinsz@jlu.edu.cn.

Funding

National Natural Science Foundation of China 81872550
6 · The paper itself

Abstract

GTPase IMAP family member 8 (GIMAP8) plays a key role in pathophysiology of several malignancies. The objective of this current research endeavor was to investigate the prognosis value of GIMAP8 in lung adenocarcinoma and examine how it relates to immunity. Expression profiles associated with GIMAP8 and related clinical details were acquired from The Cancer Genome Atlas database, and we conducted survival analysis, enrichment analysis and immune infiltration studies. Additionally, we evaluated the effect of GIMAP8 on radiation resistance of tumor by in vivo and in vitro experiments. Our results showed that lung adenocarcinoma tumor tissues exhibited lower GIMAP8 levels compared to nearby normal tissues. Furthermore, decreased GIMAP8 expression strongly correlated with poorer OS. The expression of GIMAP8 is closely related to the formation of radiation resistance in tumor cells. GSEA identified multiple signaling pathways linked to GIMAP8, including immune-related, chemokine, cell adhesion molecule, and NF-κB signaling pathways. GIMAP8 expression strongly correlated with the expression of immune checkpoint molecules, tumor mutational burden, tumor neoantigen burden, immune cells, and tumor immune microenvironment. GIMAP8 was found to have an inhibitory effect on lung adenocarcinoma and was closely related to the immune response. Moreover, GIMAP8 may also influence radiation resistance in tumors.

Indexed as

Adenocarcinoma of LungBiomarkers, TumorLung NeoplasmsAnimalsCell Line, TumorFemaleGene Expression Regulation, NeoplasticHumansMaleMicePrognosisRadiation ToleranceSignal TransductionTumor MicroenvironmentBiomarkers, TumorGIMAP8ImmunityLung adenocarcinomaPrognosisTCGA

Identifiers

PMID40316818
PMCPMC12048572

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