Evidence map›Paper›PMID 40316816›Full record

ArticleNature human behaviour2025

Preliminary evidence for enhanced auditory cortex activation and mental development after gene therapy in children with autosomal recessive deafness 9.

Jiajia Zhang, Zengzhi Guo, Changjie Pan, Chunchun Hu, Xinyang Weng, Yang-Wenyi Liu, Xiaoting Cheng, Jun Lv, Qi Cao, Hui Wang and 19 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature human behaviour, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Treating Hearing Loss: From Cochlear Implantation to Gene Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Jiajia Zhang *ENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0002-2916-0636
Zengzhi Guo *College of Medicine and Biologic Information Engineering, Northeastern University, Shenyang, China.ORCID http://orcid.org/0000-0002-0142-6981
Changjie Pan *Department of Electronic and Electrical Engineering, Southern University of Science and Technology, Shenzhen, China.
Chunchun Hu *Department of Child Health Care, Children's Hospital of Fudan University, Shanghai, China.ORCID http://orcid.org/0009-0002-3908-7548
Xinyang Weng *ENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.ORCID http://orcid.org/0009-0003-0742-3137
Yang-Wenyi LiuENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0003-0755-6098
Xiaoting ChengENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Jun LvENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Qi CaoENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Hui WangENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Yuxin ChenENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.ORCID http://orcid.org/0009-0004-6241-6535
Daqi WangENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Shaowei HuENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Mengzhao XunENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Longlong ZhangENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Zijing WangENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Honghai TangENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Biyun ZhuENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Luo GuoENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Sha YuENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0002-8487-974X
Xiaoling HuDepartment of Biomedical Engineering, Hong Kong Polytechnic University, Hong Kong, China.ORCID http://orcid.org/0000-0003-3188-3005
Lin ChenAuditory Research Laboratory, School of Life Sciences, University of Science and Technology of China, Hefei, China.ORCID http://orcid.org/0000-0002-5847-2989
Bing ChenENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Zheng-Yi ChenDepartment of Otolaryngology-Head and Neck Surgery, Graduate Program in Speech and Hearing Bioscience and Technology and Program in Neuroscience, Harvard Medical School, Boston, MA, USA.
Shan SunENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0003-2142-4307
Xiu XuDepartment of Child Health Care, Children's Hospital of Fudan University, Shanghai, China.
Huawei LiENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Fei ChenDepartment of Electronic and Electrical Engineering, Southern University of Science and Technology, Shenzhen, China.ORCID http://orcid.org/0000-0002-6988-492X
Yilai ShuENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China. yilai_shu@fudan.edu.cn.ORCID http://orcid.org/0000-0001-8893-434X

Funding

National Natural Science Foundation of China (National Science Foundation of China) 62371217National Natural Science Foundation of China (National Science Foundation of China) 82071048National Natural Science Foundation of China (National Science Foundation of China) 82171148National Natural Science Foundation of China (National Science Foundation of China) 82192864National Natural Science Foundation of China (National Science Foundation of China) 82201306National Natural Science Foundation of China (National Science Foundation of China) 82225014Science and Technology Commission of Shanghai Municipality (Shanghai Municipal Science and Technology Commission) 23J31900100Shanghai Municipal Education Commission 2023ZKZD12
6 · The paper itself

Abstract

Individuals with congenital deafness that have received gene therapy represent a unique group who experience hearing recovery and speech development. However, it is unclear how hearing-related cortex changes because of gene therapy. Here we study neural processing in ten patients using functional near-infrared spectroscopy and electroencephalography during a six-month follow-up period. Patients showed an enhancement of activation in the auditory cortex, particularly in parts of the Sylvian parietotemporal area while listening to music. Activation in the right anterior temporal lobe and left Sylvian parietotemporal area was also enhanced when listening to speech. The electroencephalography data showed that the power of the resting-state electroencephalography beta band at time points T2 and T3 was statistically significantly increased after gene therapy, and mismatch negativity amplitudes at T2 and T3 were statistically significantly higher than those at T0. The mental developmental level of the patients also increased after gene therapy. These preliminary findings illuminate the neural and cognitive effects of gene therapy, supporting its potential effectiveness in auditory and mental development.

Indexed as

Auditory CortexDeafnessGenetic TherapyAdolescentAuditory PerceptionChildChild, PreschoolElectroencephalographyFemaleHumansMaleSpectroscopy, Near-Infrared

Identifiers

PMID40316816

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.