Trial reportClinical oral investigations2025
The effect of collagen sponge placed in the socket after surgical extraction of mandibular third molars on the incidence of alveolar osteitis: a split mouth randomized controlled trial.
Trial report in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Interventions to minimize periodontal defect distal to second molar after mandibular third molar surgery: an overview of systematic reviews.Oral and maxillofacial surgery · 2025Pooled it
- Collagen-Based Delivery Systems for the Prevention of Alveolitis: A Narrative Review and Rationale for Biopharmaceutical Development Requirements.Journal of functional biomaterials · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo assess the effect of collagen plug application into the alveolar socket following surgical extraction of impacted lower third molars (IL3rdM) on pain, mouth opening, and the incidence of Alveolar Osteitis (AO). MATERIALS AND
methodsA split-mouth randomized controlled trial was conducted on patients with bilaterally partially IL3rdM. Similar surgical extraction was done on both sides, although collagen sponges were placed only in the sockets of the test sides. Pre-operative (day 1) evaluation included eruption status, pain by Visual Analogue Scale, and mouth opening by a caliper. On day 3, pain assessment was done and repeated on day 7, with mouth opening and empty sockets.
resultsThirty-one patients, 80.6% female, were included. The ages ranged from 20 to 42 years. No significant difference in pain scores was found between the two sides on day 1; however, the pain was significantly higher on the control side on days 3 (p = 0.002) and 7 (p = 0.001). The mean mouth opening was minimally larger on the test side on day 7 (p = 0.465). Only 3 cases (9.7%) of empty sockets and food debris on the control side reported pain greater than 5, and they were diagnosed as AO without significant difference (p = 238) between the two sides.
conclusionIntra-alveolar application of collagen sponge following surgical extraction of IL3rdM significantly reduced post-operative pain on days 3 and 7. Moreover, it can minimally decrease the incidence of AO. CLINICAL RELEVANCE: Surgical extraction of IL3rdM is a frequent procedure. Alleviating the pain and other complications improves the patient's quality of life.
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Registered trials
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