Evidence map›Paper›PMID 40316726›Full record

ArticleBritish journal of cancer2025

Parity, breastfeeding, and the risk of early-onset breast cancer in women with a BRCA1 pathogenic variant.

Joanne Kotsopoulos, Christopher A Maxwell, Jan Lubinski, Tomasz Huzarski, Raymond H Kim, Nadine Tung, Andrea Eisen, William Foulkes, Amber Aeilts, Susan L Neuhausen and 10 more

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In one paragraph

Article in British journal of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Joanne KotsopoulosWomen's College Research Institute, Women's College Hospital, Toronto, ON, Canada.
Christopher A MaxwellDepartment of Pediatrics, University of British Columbia, Vancouver, BC, Canada.ORCID http://orcid.org/0000-0002-0713-7136
Jan LubinskiInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Tomasz HuzarskiInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Raymond H KimDivision of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Sinai Health System, Hospital for Sick Children, Ontario Institute for Cancer Research, Department of Medicine, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-2147-8674
Nadine TungBeth Israel Deaconess Medical Center, Boston, MA, USA.
Andrea EisenToronto-Sunnybrook Regional Cancer Center, Toronto, ON, Canada.
William FoulkesMcGill Program in Cancer Genetics, Department of Oncology, McGill University, Montreal, QC, Canada.
Amber AeiltsDivision of Human Genetics, The Ohio State University Medical Center, Comprehensive Cancer Center, Columbus, OH, USA.ORCID http://orcid.org/0000-0001-8907-7853
Susan L NeuhausenDivision of Biomarkers of Early Detection and Prevention, Department of Population Sciences, City of Hope, Duarte, CA, USA.ORCID http://orcid.org/0000-0001-5053-0390
Louise BordeleauDepartment of Oncology, McMaster University, Hamilton, ON, Canada.
Rama KhokhaDepartment of Medical Biophysics, University of Toronto, Princess Margaret Cancer Centre, Toronto, ON, Canada.
Tuya PalDepartment of Medicine, Vanderbilt University, Nashville, TN, USA.
Beth KarlanDepartment of Obstetrics and Gynecology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-9451-2933
Robert FruscioClinic of Obstetrics and Gynecology, IRCCS Fondazione San Gerardo dei Tintori, Monza, Italy.ORCID http://orcid.org/0000-0001-5688-2194
Fergus CouchDivision of Experimental Pathology and Laboratory Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Ping SunWomen's College Research Institute, Women's College Hospital, Toronto, ON, Canada.
Jacek GronwaldInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Steven A NarodWomen's College Research Institute, Women's College Hospital, Toronto, ON, Canada. steven.narod@wchospital.ca.ORCID http://orcid.org/0000-0001-5798-0626
Hereditary Breast Cancer Clinical Study Group

Funding

Canadian Cancer Society Research Institute (Société Canadienne du Cancer) 703058Kreftforeningen (Norwegian Cancer Society) 194751-2017Terry Fox Research Institute (Institut de Recherche Terry Fox) TFP-185032
6 · The paper itself

Abstract

backgroundIt is not clear if breastfeeding and/or parity are associated with the risk of breast cancer among women with a germline pathogenic variant in BRCA1. We sought to evaluate the associations of these two factors with early-onset breast cancer in the BRCA1 pathogenic variant.

methodsThis case-control study included individuals with a BRCA1 pathogenic variant enroled in a longitudinal study using reproductive and disease histories ascertained at the time of enrolment. Cases had invasive breast cancer prior to age 45, and controls had no breast cancer prior to age 45. Logistic regression was used to evaluate the associations of parity and breastfeeding with cancer risk.

resultsParity per se was not associated with breast cancer risk (OR = 1.09; 95%CI 0.95-1.25); however, among women who never breastfed, the OR for parous vs. nulliparous women was 1.45 (95%CI 1.20-1.75). After matching for parity, ever breastfeeding was associated with 25% lower odds of breast cancer (95%CI 0.61-0.91), and the odds ratio was 0.53 (95%CI 0.40-0.72) for those who breastfed for 20 or more months. DISCUSSION: Our findings suggest a potential role for breastfeeding in the prevention of young-onset breast cancer among individuals with a BRCA1 pathogenic variant and provide insight into possible prevention targets.

Indexed as

BRCA1 ProteinBreast FeedingBreast NeoplasmsParityAdultAge of OnsetCase-Control StudiesFemaleGenetic Predisposition to DiseaseGerm-Line MutationHumansLongitudinal StudiesMiddle AgedPregnancyRisk FactorsBRCA1 ProteinBRCA1 protein, human

Identifiers

PMID40316726
PMCPMC12238466

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.