Evidence map›Paper›PMID 40316562›Full record

ArticleBlood cancer journal2025

CD56 expression modulates NAD+ metabolic landscape and predicts sensitivity to anti-CD38 therapies in multiple myeloma.

Giulia Giorgetti, Elena Maroto-Martin, Debora Soncini, Daniela Fenoglio, Pamela Becherini, Andrea Benzi, Silvia Ravera, Isabella Traverso, Francesco Ladisa, Francesco Lai and 14 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood cancer journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Giulia GiorgettiClinic of Hematology, Department of Internal Medicine and Medical Specialties (DiMI), University of Genoa, Genoa, Italy.ORCID http://orcid.org/0009-0009-7494-0154
Elena Maroto-MartinJerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Debora SonciniClinic of Hematology, Department of Internal Medicine and Medical Specialties (DiMI), University of Genoa, Genoa, Italy.
Daniela FenoglioIRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Pamela BecheriniClinic of Hematology, Department of Internal Medicine and Medical Specialties (DiMI), University of Genoa, Genoa, Italy.
Andrea BenziDepartment of Experimental Medicine (DIMES), University of Genoa, Genova, Italy.
Silvia RaveraIRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Isabella TraversoClinic of Hematology, Department of Internal Medicine and Medical Specialties (DiMI), University of Genoa, Genoa, Italy.
Francesco LadisaClinic of Hematology, Department of Internal Medicine and Medical Specialties (DiMI), University of Genoa, Genoa, Italy.ORCID http://orcid.org/0009-0008-2868-739X
Francesco LaiIRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Giulia RivoliHematology and Hematopoietic Stem Cell Transplantation Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Dario TruffelliClinic of Hematology, Department of Internal Medicine and Medical Specialties (DiMI), University of Genoa, Genoa, Italy.
Aimable NahimanaService and Central Laboratory of Hematology, Departments of Oncology and Medical Laboratory and Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-4968-3167
Antonia CagnettaClinic of Hematology, Department of Internal Medicine and Medical Specialties (DiMI), University of Genoa, Genoa, Italy.
Fabio GuoloClinic of Hematology, Department of Internal Medicine and Medical Specialties (DiMI), University of Genoa, Genoa, Italy.
Chiara R M UrasJerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Anaïs SchavgoulidzeJerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Jessica Fong NgJerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Alessio NencioniIRCCS Ospedale Policlinico San Martino, Genoa, Italy.ORCID http://orcid.org/0000-0001-5068-8884
Santina BruzzoneIRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Nikhil C MunshiJerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7344-9795
Roberto Massimo LemoliClinic of Hematology, Department of Internal Medicine and Medical Specialties (DiMI), University of Genoa, Genoa, Italy.
Mariateresa FulcinitiJerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1432-9742
Michele CeaClinic of Hematology, Department of Internal Medicine and Medical Specialties (DiMI), University of Genoa, Genoa, Italy. michele.cea@unige.it.ORCID http://orcid.org/0000-0003-3345-0799

Funding

Targeting Genomic Instability and Evolution in MyelomaP01CA155258 · NCI · DANA-FARBER CANCER INST · PI Nikhil C. Munshi · 2011 to 2026
$32.5M
Associazione Italiana per la Ricerca sul Cancro (Italian Association for Cancer Research) IG#23438NCI NIH HHS P01 CA155258Sanofi ISS-SGZ-04/22
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40316562
PMCPMC12048669

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.