ArticleDental materials : official publication of the Academy of Dental Materials2025
Optimization of dental adhesive interfaces using tissue biomodulation with DESIGNER biopolymers.
Article in Dental materials : official publication of the Academy of Dental Materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Enhancing dentin bonding with catechol-based monomers by tailoring photoinitiator systems to overcome radical inhibition.Dental materials : official publication of the Academy of Dental Materials · 2026Article
- Long-term nano-dynamic mechanical analysis and micro-permeability of adhesive interface components using four AB-type proanthocyanidin neutral primers.Journal of dentistry · 2026Article
- Advanced biomechanics and stability of the resin-dentin complex via modular A- and B-type proanthocyanidins.Biomaterials · 2026Article
- A Bioinspired Approach to Mechanically Reinforce Collagen-Rich Tissues Using Modularly Defined Stilbenoids.Biopolymers · 2026Article
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Authors and funding
7 authors.
Funding
Abstract
objectiveTo investigate the modulatory effects of four proanthocyanidin-DESIGNERS (PAC-DESIGNERs) on the long-term bond strength of the resin-adhesive interface, the degree of conversion of resin monomers, the chemical-mechanical properties of dentin matrix, and cell biocompatibility.
methodsStandardized formulations of PACs with a dominant degree of polymerization - DP (trimers: PM-AB and CV-AB; tetramers: PM-ABA and CV-ABB) were prepared from two sources of AB-Type PACs using a DESIGNER approach. Resin-dentin interface was assessed after 24 hours and 1 year using a microtensile bond strength (µTBS) test. The degree of conversion (DC) of resin monomers and chemical analysis of the dentin matrix were analyzed by ATR-FTIR spectroscopy. The viscoelastic properties of the dentin matrix were assessed by dynamic mechanical analysis (DMA). Cell viability was analyzed using a 3D cell culture model. Data analysis using two- and one-way ANOVA and post-hoc tests (α = 0.05).
resultsAll PAC-DESIGNER biomodulation increased the µTBS when compared to control (p < 0.05), regardless of source, DP, and aging. The DC of resin adhesive was not negatively impacted, and an increase in DC was observed with the incorporation of PM-AB and PM-ABA DESIGNERs (p < 0.05). PAC-DESIGNER treatment also increased the dentin matrix complex modulus (153-79 MPa) and storage modulus (151-78 MPa) when compared to control (∼9 MPa, p < 0.05). All DESIGNERs decreased the intensity of amide II/CH SIGNIFICANCE: All PAC-DESIGNERs optimized the dentin-resin µTBS. The different molecular structures played a modulatory role in the chemical-mechanical properties of the dentin matrix, the degree of conversion of adhesive, and cell biocompatibility.
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